Department of Dermatology, Molecular Dermatology Research Center, Faghihi Hospital, Shiraz University of Medical Sciences , Shiraz , Iran .
J Dermatolog Treat. 2014 Jun;25(3):249-50. doi: 10.3109/09546634.2013.832135. Epub 2013 Aug 27.
Molluscum contagiosum (MC) is a common cutaneous viral infection. Potassium hydroxide (KOH), as a strong alkali, and cryotherapy have been used for its treatment. The objective of this study was to compare these two treatment modalities.
30 patients, aged between 1 and 24 years of age, were randomly divided into 2 groups: 15 were treated with KOH 10% solution and 15 were treated with cryotherapy. KOH 10 % was applied by the patient or their parent(s) two times a day until the lesions disappeared completely. Cryotherapy was performed with liquid nitrogen spray, repeated weekly for 4 weeks. The assessment of response and side effects were performed weekly for 4 weeks.
In the KOH group, 86.6% had complete response, 6.7% had partial response and 6.7% had no response after 4 weeks. In the cryotherapy group, 93.3% had complete response and 6.7% had partial response. There was no statistically significant difference between the two groups (p > 0.05). Postinflammatory hyperpigmentation, as a side effect, was mostly noted with cryotherapy.
Both treatment modalities were equally effective. Since KOH is inexpensive and confers better cosmetic results compared to cryotherapy, it can be used as a suitable treatment modality for MC.
传染性软疣（MC）是一种常见的皮肤病毒性感染。氢氧化钾（KOH）作为一种强碱，以及冷冻疗法已被用于其治疗。本研究的目的是比较这两种治疗方式。
30 名年龄在 1 至 24 岁之间的患者被随机分为两组：15 名患者接受 10%KOH 溶液治疗，15 名患者接受冷冻疗法。患者或其父母每天两次涂抹 10%KOH，直至皮损完全消失。冷冻疗法使用液氮喷雾进行，每周重复一次，共 4 周。每周评估一次反应和副作用，共 4 周。
在 KOH 组，4 周后，86.6%的患者完全缓解，6.7%的患者部分缓解，6.7%的患者无反应。在冷冻疗法组，93.3%的患者完全缓解，6.7%的患者部分缓解。两组之间无统计学差异（p>0.05）。冷冻疗法后，炎症后色素沉着过度是最常见的副作用。
两种治疗方式同样有效。由于 KOH 价格低廉，与冷冻疗法相比美容效果更好，因此可以作为 MC 的一种合适的治疗方式。
