Ogrendik Mesut
Division of Rheumatology, Nazilli State Hospital, Nazilli 09800, Turkey.
Discov Med. 2012 May;13(72):349-55.
There is a significant association between rheumatoid arthritis (RA) and periodontal disease (PD). Patients with longstanding active RA have been found to have a substantially increased frequency of PD compared with healthy subjects. Further, patients with PD have been shown to have a higher prevalence of RA than patients without periodontitis. Antibodies to Gram-negative, anaerobic periodontal pathogens such as Porphyromonas gingivalis, Prevotella intermedia, Prevotella melaninogenica, and Tannerella forsythia have been detected in the serum and synovial fluid of RA patients. These pathogens have also been identified in the synovial fluid of RA patients, with higher levels of bacterial DNA in RA patients than in controls. This review examines the association between periodontopathic bacteria and the etiology of RA.
类风湿关节炎（RA）与牙周病（PD）之间存在显著关联。研究发现，与健康受试者相比，长期患有活动性RA的患者患PD的频率大幅增加。此外，与无牙周炎的患者相比，PD患者患RA的患病率更高。在RA患者的血清和滑液中已检测到针对革兰氏阴性厌氧牙周病原体的抗体，如牙龈卟啉单胞菌、中间普氏菌、产黑色素普氏菌和福赛坦纳菌。在RA患者的滑液中也已鉴定出这些病原体，RA患者的细菌DNA水平高于对照组。本综述探讨了牙周病细菌与RA病因之间的关联。
