类风湿关节炎是由牙周病原体引起的自身免疫性疾病。
Rheumatoid arthritis is an autoimmune disease caused by periodontal pathogens.
机构信息
Division of Physical Therapy and Rheumatology, Nazilli State Hospital, Nazilli, Turkey.
出版信息
Int J Gen Med. 2013 May 24;6:383-6. doi: 10.2147/IJGM.S45929. Print 2013.
Abstract
A statistically significant association between periodontal disease (PD) and systemic diseases has been identified. Rheumatoid arthritis (RA), which is a chronic inflammatory joint disease, exhibits similar characteristics and pathogenesis to PD. The association between RA and PD has been investigated, and numerous publications on this subject exist. Approximately 20 bacterial species have been identified as periodontal pathogens, and these organisms are linked to various types of PD. The most analyzed species of periodontopathic bacteria are Porphyromonas gingivalis, Prevotella intermedia, Tannerella forsythia, and Aggregatibacter actinomycetemcomitans. Antibodies and DNA from these oral pathogens have been isolated from the sera and synovial fluids of RA patients. This rapid communication describes the role of periodontal pathogens in the etiopathogenesis of RA.
摘要
已经确定牙周病 (PD) 与系统性疾病之间存在统计学关联。类风湿性关节炎 (RA) 是一种慢性炎症性关节疾病，其表现出与 PD 相似的特征和发病机制。RA 和 PD 之间的关联已经被研究过，并且有许多关于这个主题的出版物。已经确定大约 20 种细菌种类是牙周病原体，这些生物体与各种类型的 PD 有关。最分析的牙周病细菌种类是牙龈卟啉单胞菌、中间普氏菌、福赛斯坦纳菌和伴放线放线杆菌。RA 患者的血清和滑液中已经分离出这些口腔病原体的抗体和 DNA。本快速通讯描述了牙周病原体在 RA 发病机制中的作用。
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