Division of Rheumatology, Nazilli State Hospital, Nazilli, Turkey.
Mod Rheumatol. 2009;19(5):453-6. doi: 10.1007/s10165-009-0194-9. Epub 2009 Jun 24.
The purpose of this review is to evaluate the association between rheumatoid arthritis (RA) and periodontopathic bacteria. Clinical studies of RA and periodontal disease have provided evidence for a significant association between the two disorders. Patients with long-standing active RA have a substantially increased frequency of periodontal disease compared with that among healthy subjects. High levels of oral anaerobic bacterial antibodies have been found in the serum and synovial fluid of RA patients. Porphyromonas gingivalis, Tannerella forsythensis, and Prevotella intermedia have been identified in RA synovial fluid. Ornidazole, levofloxacin, and clarithromycin are used in the treatment of infections caused by anaerobic bacteria. These antibiotics have been shown to be effective against RA. The evidence in this review indicates that oral bacteria directly associate with etiopathogenesis of RA.
本文旨在评估类风湿关节炎（RA）与牙周病致病菌之间的关联。RA 和牙周病的临床研究为这两种疾病之间存在显著相关性提供了证据。与健康受试者相比，长期患有活动期 RA 的患者牙周病的发病率显著增加。RA 患者的血清和滑液中发现高水平的口腔厌氧细菌抗体。RA 滑膜液中已鉴定出牙龈卟啉单胞菌、福赛斯坦纳菌和中间普氏菌。奥硝唑、左氧氟沙星和克拉霉素用于治疗厌氧菌引起的感染。这些抗生素已被证明对 RA 有效。本综述中的证据表明，口腔细菌与 RA 的发病机制直接相关。
