Sarto F, Trevisan A, Tomanin R, Canova A, Fiorentino M
Istituto di Medicina del Lavoro dell'Università, Padova, Italy.
Am J Ind Med. 1990;18(6):689-95. doi: 10.1002/ajim.4700180607.
In this study we examined the structural chromosomal aberrations (CA) and sister chromatid exchanges (SCE) of 12 nurses handling moderate quantities of antineoplastic drugs. Urinary thioethers were also measured to assess the potential exposure to alkylating drugs. Two control groups with similar mean age and smoking habits and working in the same hospital were also studied: 1) control clerks and 2) control nurses. Our study did not show any clear increase of chromosomal damage in exposed nurses as compared to controls. However, CA in control nurses were significantly increased (p = 0.05) with respect to control clerks. The results of baseline urinary excretion of thioethers were statistically higher (p less than 0.02) in exposed subjects than in control clerks.
在本研究中，我们检测了12名接触中等剂量抗肿瘤药物的护士的染色体结构畸变（CA）和姐妹染色单体交换（SCE）情况。还测定了尿硫醚，以评估接触烷化剂药物的潜在可能性。我们还研究了两个平均年龄和吸烟习惯相似且在同一家医院工作的对照组：1）对照职员和2）对照护士。与对照组相比，我们的研究未显示出接触药物的护士的染色体损伤有任何明显增加。然而，对照护士的CA相对于对照职员显著增加（p = 0.05）。接触药物的受试者的硫醚基线尿排泄结果在统计学上高于对照职员（p小于0.02）。
