大鼠从饥饿到进食转变过程中胸肌和骨骼肌的葡萄糖利用与处置
Glucose utilization and disposal in cardiothoracic and skeletal muscles during the starved-to-fed transition in the rat.
作者信息
Sugden M C, Liu Y L, Holness M J
机构信息
Department of Biochemistry, Queen Mary and Westfield College, London, U.K.
出版信息
Biochem J. 1990 Nov 15;272(1):133-7. doi: 10.1042/bj2720133.
Abstract
Glucose utilization indices (GUI) increased to fed values in diaphragm and oxidative skeletal muscles and exceeded fed values in non-oxidative muscles within 2 h of re-feeding chow to 48 h-starved rats. Cardiac GUI reached fed values only after 7 h. Glycogen deposition accounted for most of the glucose phosphorylated in skeletal muscle over the first 2 h in oxidative muscles and over the first 4 h in non-oxidative muscles. In oxidative muscles, the contribution of glycogen deposition to total glucose 6-phosphate disposal diminished as re-feeding was extended from 2 to 6 h.
摘要
给饥饿48小时的大鼠重新喂食普通饲料后2小时内，膈肌和氧化型骨骼肌中的葡萄糖利用指数（GUI）升至进食状态时的值，非氧化型肌肉中的该指数超过进食状态时的值。心脏的GUI仅在7小时后达到进食状态时的值。在最初2小时内，氧化型肌肉中糖原沉积占骨骼肌中磷酸化葡萄糖的大部分，在最初4小时内，非氧化型肌肉中糖原沉积占大部分。在氧化型肌肉中，随着重新喂食时间从2小时延长至6小时，糖原沉积对总6-磷酸葡萄糖处理的贡献减少。
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