大鼠饥饿至进食过渡期间骨骼肌糖原的合成
Skeletal-muscle glycogen synthesis during the starved-to-fed transition in the rat.
作者信息
Holness M J, Schuster-Bruce M J, Sugden M C
机构信息
Department of Chemical Pathology, London Hospital Medical College, U.K.
出版信息
Biochem J. 1988 Sep 15;254(3):855-9. doi: 10.1042/bj2540855.
Abstract
The pattern of glycogen deposition in skeletal muscles of varying fibre composition was examined in rats during the starved-to-fed transition. In all the muscles studied, glycogen concentrations steadily increased during the first 8 h after chow re-feeding, and the fed value was exceeded. Rates of glycogen deposition varied, not with muscle fibre composition, but with the extent of glycogen depletion during starvation. There was no evidence for skeletal-muscle glycogen breakdown during the period of hepatic glycogenesis, making it unlikely that recycling of carbon from muscle glycogen to lactate is quantitatively important for the provision of glycogenic precursors to the liver, but moderate glycogen loss was observed from 8 to 24 h after re-feeding, when the liver is in the lipogenic mode. The factors influencing glucose disposal by skeletal muscle after re-feeding are discussed.
摘要
在饥饿到进食的转变过程中，研究了不同纤维组成的大鼠骨骼肌中糖原沉积的模式。在所有研究的肌肉中，重新喂食食物后的前8小时内，糖原浓度稳步增加，并超过了进食后的水平。糖原沉积速率各不相同，不是取决于肌肉纤维组成，而是取决于饥饿期间糖原耗竭的程度。在肝脏糖原生成期间，没有证据表明骨骼肌糖原分解，这使得肌肉糖原中的碳循环转化为乳酸，从而为肝脏提供糖原前体在数量上不太可能具有重要意义，但在重新喂食后8至24小时观察到适度的糖原损失，此时肝脏处于脂肪生成模式。本文讨论了重新喂食后影响骨骼肌葡萄糖代谢的因素。
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本文引用的文献
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Effect of muscle glycogen content on glucose uptake following exercise.运动后肌肉糖原含量对葡萄糖摄取的影响。
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Effects of starvation and exercise on concentrations of citrate, hexose phosphates and glycogen in skeletal muscle and heart. Evidence for selective operation of the glucose-fatty acid cycle.饥饿和运动对骨骼肌及心脏中柠檬酸、己糖磷酸和糖原浓度的影响。葡萄糖-脂肪酸循环选择性运作的证据。
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10
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