Manzano A, Pérez-Segura P
Oncology Department, Hospital Clínico San Carlos, 28040 Madrid, Spain.
ScientificWorldJournal. 2012;2012:327341. doi: 10.1100/2012/327341. Epub 2012 Apr 29.
Colorectal cancer (CRC) is presently one of the most common causes of cancer-related death in our setting and affects a great number of people each year. Screening strategies are commonly used but they do not seem enough to avoid CRC development or prevent completely its mortality. Because of this fact other prevention strategies have gained interest in recent years. Chemoprevention seems to be an attractive option in this setting and several drugs have been studied in this field. This review is focused on salicylates, nonsteroidal anti-inflammatory drugs (NSAIDs) and cycloxygenase-2 inhibitors (COXIBs), whose mechanism of action could be directly related to colon cancer chemoprevention.
在我们所处的环境中，结直肠癌（CRC）目前是癌症相关死亡的最常见原因之一，每年影响大量人群。筛查策略普遍使用，但似乎不足以避免结直肠癌的发生或完全预防其致死率。鉴于此，近年来其他预防策略受到关注。在这种情况下，化学预防似乎是一个有吸引力的选择，并且已经在该领域研究了几种药物。本综述聚焦于水杨酸盐、非甾体抗炎药（NSAIDs）和环氧合酶-2抑制剂（COXIBs），其作用机制可能与结肠癌化学预防直接相关。
