Kaponis Apostolos, Iwabe Tomio, Taniguchi Fuminori, Ito Masayuki, Deura Imari, Decavalas George, Terakawa Naoki, Harada Tasuku
Department of Obstetrics and Gynecology, Patras University School of Medicine, Patra, Greece.
Front Biosci (Schol Ed). 2012 Jun 1;4(4):1213-34. doi: 10.2741/s327.
The nuclear factor kappaB (NF-kappaB) is a ubiquitously expressed transcription factor playing vital roles in innate immunity and other processes involving cellular survival, proliferation, and differentiation. This review highlights the importance of NF-kappaB in the pathophysiology of endometriosis. Constitutive activation of NF-kappaB has been shown in endometriotic lesions. Complex interactions of NF-kappaB with steroid receptors and apoptotic molecules in endometriosis resulting in opposing roles of NF-kappaB are discussed. NF-kappaB regulates the expression of cytokines mediating autocrine self-amplifying cycles of cytokine release and NF-kappaB activation, leading to maintenance of inflammatory reactions in endometriosis. NF-kappaB can contribute to the increased ability of endometriotic cells to invade and adhere to the peritoneal surface by regulating the expression of matrix metaloproteinases. We are presenting the role of NF-kappaB to regulate vascularization and oxidative stress in endometriotic cells. Effects of drugs used for the treatment of endometriosis on NF-kappaB pathway are presented and we show how drugs that inhibit the NF-kappaB can mediate the progression of endometriosis. Novel therapeutic strategies involving the NF-kappaB and applied in endometriosis are also discussed.
核因子κB（NF-κB）是一种广泛表达的转录因子，在固有免疫以及其他涉及细胞存活、增殖和分化的过程中发挥着至关重要的作用。本综述强调了NF-κB在子宫内膜异位症病理生理学中的重要性。已证实在子宫内膜异位症病灶中NF-κB存在组成性激活。本文讨论了在子宫内膜异位症中NF-κB与类固醇受体和凋亡分子之间的复杂相互作用，这些相互作用导致了NF-κB的相反作用。NF-κB调节细胞因子的表达，这些细胞因子介导细胞因子释放和NF-κB激活的自分泌自我放大循环，从而导致子宫内膜异位症中炎症反应的维持。NF-κB可通过调节基质金属蛋白酶的表达，促进子宫内膜异位症细胞侵袭和黏附于腹膜表面能力的增强。我们阐述了NF-κB在调节子宫内膜异位症细胞血管生成和氧化应激中的作用。介绍了用于治疗子宫内膜异位症的药物对NF-κB信号通路的影响，并且展示了抑制NF-κB的药物如何介导子宫内膜异位症的进展。还讨论了涉及NF-κB并应用于子宫内膜异位症的新型治疗策略。
