Department of Gynecology, Women's Hospital, School of Medicine, Zhejiang University, Xueshi Road, Hangzhou 310006, China.
Zhejiang Provincial Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases, Women's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China.
Int J Biol Sci. 2022 Jul 4;18(11):4400-4413. doi: 10.7150/ijbs.72707. eCollection 2022.
Endometriosis remains a common but challenging gynecological disease among reproductive-aged women with an unclear pathogenesis and limited therapeutic options. Numerous pieces of evidence suggest that NF-κB signaling, a major regulator of inflammatory responses, is overactive in endometriotic lesions and contributes to the onset, progression, and recurrence of endometriosis. Several factors, such as estrogen, progesterone, oxidative stress, and noncoding RNAs, can regulate NF-κB signaling in endometriosis. In the present review, we discuss the mechanisms by which these factors regulate NF-κB during endometriosis progression and provide an update on the role of NF-κB in affecting endometriotic cells, peritoneal macrophages (PMs) as well as endometriosis-related symptoms, such as pain and infertility. Furthermore, the preclinical drugs for blocking NF-κB signaling in endometriosis are summarized, including plant-derived medicines, NF-κB inhibitors, other known drugs, and the potential anti-NF-κB drugs predicted through the Drug-Gene Interaction Database. The present review discusses most of the studies concerning the multifaceted role of NF-κB signaling in endometriosis and provides a summary of NF-κB-targeted treatment in detail.
子宫内膜异位症仍然是生殖期妇女中常见但具有挑战性的妇科疾病，其发病机制尚不清楚，治疗选择有限。大量证据表明，核因子-κB 信号通路是炎症反应的主要调节因子，在子宫内膜异位症病变中过度活跃，导致子宫内膜异位症的发生、进展和复发。许多因素，如雌激素、孕激素、氧化应激和非编码 RNA 等，可以调节子宫内膜异位症中的 NF-κB 信号通路。在本综述中，我们讨论了这些因素在子宫内膜异位症进展过程中调节 NF-κB 的机制，并介绍了 NF-κB 在影响子宫内膜异位症细胞、腹膜巨噬细胞（PMs）以及与子宫内膜异位症相关的症状（如疼痛和不孕）中的作用。此外，还总结了用于阻断子宫内膜异位症中 NF-κB 信号通路的临床前药物，包括植物来源的药物、NF-κB 抑制剂、其他已知药物以及通过药物-基因相互作用数据库预测的潜在抗 NF-κB 药物。本综述讨论了 NF-κB 信号通路在子宫内膜异位症中的多方面作用的大多数研究，并详细总结了 NF-κB 靶向治疗。
