Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Neurology, Warsaw, Poland.
Neuropsychobiology. 2012 Jun;65(4):206-15. doi: 10.1159/000337001. Epub 2012 May 25.
Both cognitive impairment and formal thought disorder (communication disturbances) found in patients with schizophrenia are also commonly observed in their relatives. Recently, the role of such deficits as putative endophenotypes of schizophrenia has been proposed. However, in a majority of studies, the families of adult patients were assessed whereas the relatives of early-onset psychotic subjects were rarely studied. The aim of our study was to evaluate the presence of cognitive impairment and formal thought disorders in parents of adolescents with a diagnosis of schizophrenia spectrum disorder (SSD) and in matched healthy controls.
Thirty-eight parents of 29 SSD adolescents and 38 healthy controls were assessed with a battery of neurocognitive tests and the Thought, Language and Communication Scale.
Parents of schizophrenia patients showed an increased tendency for perseverative thinking when compared to matched healthy controls. No statistically significant differences in cognitive functioning were observed between the groups.
These results may suggest the need for further exploration of communication disturbances as a potential endophenotypic marker of early-onset schizophrenia.
在精神分裂症患者中发现的认知障碍和形式思维障碍（交流障碍），在其亲属中也很常见。最近，这些缺陷被认为是精神分裂症的潜在内表型。然而，在大多数研究中，都是评估成年患者的家属，而很少研究早期发病的精神病患者的亲属。我们的研究目的是评估诊断为精神分裂症谱系障碍（SSD）的青少年患者的父母，以及相匹配的健康对照组，是否存在认知障碍和形式思维障碍。
38 名 29 名 SSD 青少年的父母和 38 名健康对照组接受了一系列神经认知测试和思维、语言和沟通量表的评估。
与相匹配的健康对照组相比，精神分裂症患者的父母表现出更倾向于持续思维。两组在认知功能方面没有统计学上的显著差异。
这些结果可能表明，有必要进一步探索交流障碍，作为早期精神分裂症的潜在内表型标记。
