Arbelle S, Magharious W, Auerbach J G, Hans S L, Marcus J, Styr B, Caplan R
Department of Psychiatry, Ben-Gurion University, Beersheba, Israel.
Isr J Psychiatry Relat Sci. 1997;34(3):210-21.
We examined potential early markers of schizophrenia using measures of formal thought disorder in offspring of parents with schizophrenia, other mental illness and no mental illness.
Two blind raters coded formal thought disorder in adolescent/early adult offspring of 42 schizophrenic, 39 other mental illness, and 36 no mental illness parents. In addition to parental diagnosis, we compared the individual offspring diagnosis with severity of formal thought disorder. Within the schizophrenia, other mental illness and no mental illness offspring groups, we examined the relationship between severity of formal thought disorder and performance on cognitive and motor tasks.
There were no statistically significant differences in formal thought disorder by parent or offspring diagnoses. Within the offspring group of parents with schizophrenia, the subjects with higher formal thought disorder scores performed significantly worse on the cognitive battery than those with lower formal thought disorder scores. Offspring of the other mental illness group with higher formal thought disorder scores, however, showed more deficits on motor tasks than those with lower formal thought disorder scores.
Formal thought disorder may reflect underlying cognitive dysfunction in the offspring of parents with schizophrenia. Motor dysfunction in the offspring of parents with other psychiatric illness might be associated with formal thought disorder.
我们使用形式思维障碍测量方法，对患有精神分裂症、其他精神疾病及无精神疾病的父母的后代进行研究，以探寻精神分裂症潜在的早期标志物。
两名盲评者对42名精神分裂症患者、39名患有其他精神疾病患者及36名无精神疾病患者的青春期/成年早期后代的形式思维障碍进行编码。除了父母的诊断结果外，我们还将个体后代的诊断结果与形式思维障碍的严重程度进行了比较。在精神分裂症、其他精神疾病及无精神疾病的后代组中，我们研究了形式思维障碍的严重程度与认知和运动任务表现之间的关系。
根据父母或后代的诊断，形式思维障碍在统计学上无显著差异。在精神分裂症患者的后代组中，形式思维障碍得分较高的受试者在认知测试中的表现明显比得分较低的受试者差。然而，在其他精神疾病组中，形式思维障碍得分较高的后代在运动任务上的缺陷比得分较低的后代更多。
形式思维障碍可能反映了精神分裂症患者后代潜在的认知功能障碍。患有其他精神疾病的父母的后代的运动功能障碍可能与形式思维障碍有关。
