Remberk Barbara, Namysłowska Irena, Rybakowski Filip
Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Neurology, Warsaw, Poland.
Neuro Endocrinol Lett. 2012;33(3):347-55.
Although formal thought disorder and cognitive impairment are key features of schizophrenia, only a few studies evaluated both in adolescent population.
32 inpatients with early-onset schizophrenia spectrum disorders (SSD) and 32 matched healthy controls were studied with Thought, Language and Communication Scale and battery of neurocognitive tests and SSD subjects were also assessed with Positive and Negative Syndrome Scale and Clinical Global Impression Scale.
Patients presented impairment in both cognitive functioning and formal thought processes. Communication disturbances correlated with executive and verbal fluency dysfunction.
Communication disturbances in adolescent SSD patients may have both dysexecutive and dyssemantic origin.
尽管形式思维障碍和认知损害是精神分裂症的关键特征，但仅有少数研究在青少年群体中对二者进行了评估。
对32例早发性精神分裂症谱系障碍（SSD）住院患者和32例匹配的健康对照者进行了思维、语言和交流量表以及一系列神经认知测试研究，并且使用阳性与阴性症状量表和临床总体印象量表对SSD患者进行了评估。
患者在认知功能和形式思维过程方面均出现损害。交流障碍与执行功能和言语流畅性功能障碍相关。
青少年SSD患者的交流障碍可能源于执行功能障碍和语义障碍。
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