Service Neuro-Diagnostique et Neuro-Interventionnel, Département de l'Imagerie et Science de l'Information Médical, University Hospitals of Geneva, Geneva, Switzerland.
AJNR Am J Neuroradiol. 2012 Dec;33(11):2123-8. doi: 10.3174/ajnr.A3126. Epub 2012 May 31.
Brain MR imaging is routinely performed in the work-up of suspected PD, yet its role is essentially limited to the exclusion of other pathologies. We performed a pattern-recognition analysis based on DTI data to detect subjects with PD at the individual level.
We included 40 consecutive patients with Parkinsonism suggestive of PD who had DTI at 3T, brain (123)I ioflupane SPECT (DaTSCAN), and extensive neurologic testing including follow-up (17 PD: age range, 67.8 ± 6.7 years; 9 women; 23 Other: consisting of atypical forms of Parkinsonism; age range, 67.2 ± 9.7 years; 7 women). Data analysis included group-level TBSS and individual-level SVM classification.
At the group level, patients with PD versus Other had spatially consistent increase in FA and decrease in RD and MD in a bilateral network, predominantly in the right frontal white matter. At the individual level, SVM correctly classified patients with PD at the individual level with accuracies up to 97%.
Support vector machine-based pattern recognition of DTI data provides highly accurate detection of patients with PD among those with suspected PD at an individual level, which is potentially clinically applicable. Because most suspected subjects with PD undergo brain MR imaging, already existing MR imaging data may be reused; this practice is very cost-efficient.
脑磁共振成像（MR 成像）在疑似帕金森病（PD）的检查中常规进行，但它的作用主要限于排除其他病变。我们进行了一项基于弥散张量成像（DTI）数据的模式识别分析，以在个体水平上检测 PD 患者。
我们纳入了 40 例连续的帕金森病样运动障碍患者，这些患者在 3T 磁共振成像仪上行 DTI 检查，并行脑（123）碘代异丙基安非他命 SPECT（DaTSCAN）检查和广泛的神经学测试，包括随访（17 例 PD：年龄范围为 67.8±6.7 岁；9 例女性；23 例其他：包括不典型帕金森病形式；年龄范围为 67.2±9.7 岁；7 例女性）。数据分析包括组水平 TBSS 和个体水平 SVM 分类。
在组水平上，PD 患者与其他患者相比，双侧额顶叶白质存在 FA 值升高、 RD 值和 MD 值降低的空间一致性改变。在个体水平上，SVM 能够以高达 97%的准确率正确分类 PD 患者。
基于支持向量机的 DTI 数据分析可以在个体水平上高度准确地检测疑似 PD 患者中的 PD 患者，这具有潜在的临床应用价值。因为大多数疑似 PD 患者已经进行了脑 MR 成像，所以可以重复使用已有的 MR 成像数据；这种做法非常具有成本效益。
