Department of Pharmacy University of Peshawar, 25120, Peshawar, Pakistan.
BMC Complement Altern Med. 2012 May 2;12:59. doi: 10.1186/1472-6882-12-59.
Pyrexia, algesia and inflammation are associated with several pathological conditions. Synthetic drugs available for the treatment of these conditions cause multiple unwanted effects. Several studies are ongoing worldwide to find natural healing agents with better safety profile. The current study was thus aimed at evaluating antipyretic, analgesic and anti-inflammatory activities of the methanolic extract of whole plant of V. betonicifolia (VBME).
VBME was employed to assess antipyretic activity in yeast induced hyperthermia. Analgesic profile was ascertained in acetic acid induced writhing, hot plat and tail immersion test. Nevertheless, the anti-inflammatory activity was tested in carrageenan induced paw edema and histamine induced inflammatory tests. BALB/c mice were used at test doses of 100, 200 and 300 mg/kg body weight intra peritoneally (i.p).
In yeast induced pyrexia, VBME demonstrated dose dependently (78.23%) protection at 300 mg/kg, similar to standard drug, paracetamol (90%) at 150 mg/kg i.p. VBME showed a dose dependent analgesia in various pain models i.e. acetic acid, hot plat and tail immersion having 78.90%, 69.96% and 68.58% protection respectively at 300 mg/kg. However, the analgesic action of VBME was completely antagonized by the injection of naloxone like opiate antagonists. Similarly carrageenan and histamine induces inflammation was significantly antagonized by VBME, 66.30% and 60.80% respectively at 300 mg/kg.
It is concluded that VBME has marked antipyretic, analgesic and anti-inflammatory activities in various animal models and this strongly supports the ethnopharmacological uses of Viola betonicifolia as antipyretic, analgesic and anti-inflammatory plant.
发热、疼痛和炎症与多种病理状况有关。用于治疗这些病症的合成药物会引起多种不良反应。目前，全世界正在进行多项研究，以寻找具有更好安全性的天然愈合剂。因此，本研究旨在评估全草醉鱼草（VBME）的甲醇提取物的解热、镇痛和抗炎活性。
采用酵母诱导发热法评价 VBME 的解热作用。在醋酸诱导扭体、热板和尾部浸入试验中确定镇痛作用。然而，在角叉菜胶诱导的足肿胀和组胺诱导的炎症试验中测试了抗炎活性。BALB/c 小鼠以 100、200 和 300 mg/kg 体重的剂量腹膜内（i.p.）给药。
在酵母诱导的发热中，VBME 在 300 mg/kg 时表现出剂量依赖性（78.23%）保护作用，与标准药物扑热息痛（150 mg/kg，i.p.）相似。VBME 在各种疼痛模型中表现出剂量依赖性的镇痛作用，即在醋酸、热板和尾部浸入试验中分别具有 78.90%、69.96%和 68.58%的保护作用，在 300 mg/kg 时。然而，VBME 的镇痛作用被阿片类拮抗剂纳洛酮完全拮抗。同样，VBME 显著拮抗角叉菜胶和组胺诱导的炎症，分别在 300 mg/kg 时抑制 66.30%和 60.80%。
VBME 在各种动物模型中具有显著的解热、镇痛和抗炎活性，这强烈支持醉鱼草作为解热、镇痛和抗炎植物的民族药理学用途。
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