Faraldi Francesco, Papa Vincenzo, Santoro Debora, Rasà Daria, Mazza Annamaria L, Rabbione Maria M, Russo Simona
Department of Ophthalmology III, Presidio Ospedaliero Oftalmico, Torino, Italy.
Clin Ophthalmol. 2012;6:727-31. doi: 10.2147/OPTH.S31776. Epub 2012 May 9.
The aim of this study was to investigate the effects of an ophthalmic gel containing sodium hyaluronate and xanthan gum in addition to the antibiotic netilmicin in the management of traumatic corneal abrasions.
PATIENTS WITH TRAUMATIC CORNEAL ABRASIONS WERE RANDOMLY TREATED AS FOLLOWS: Group A (n = 20) with an occlusive patching for 12 hours plus one drop of an eye gel containing 0.15% sodium hyaluronate, 1% xanthan gum and 0.3% netilmicin qid for 5 days; and Group B (n = 20) with an occlusive patching for 2-3 days plus one application of 0.3% netilmicin ophthalmic ointment qid for 5 days. All patients were evaluated after the third and seventh day by slit-lamp examination, fluorescein staining, and corneal defect photograph in order to assess corneal re-epithelialization. Conjunctival hyperaemia, lid oedema, subjective symptoms of discomfort, and conjunctival swabs were also evaluated.
No statistically significant difference was observed between the groups in terms of the extent of corneal healing after 3 days of treatment. Both treatments were also highly effective in decreasing the erosion score and the conjunctival hyperemia (P < 0.0001, P < 0.005, respectively) without any significant difference between the two types of treatment. Subjective symptoms of discomfort and conjunctival swabs were also evaluated.
In the management of traumatic corneal abrasions, the administration of an eye gel containing sodium hyaluronate and xanthan gum is able to reduce the length of occlusive patching. In addition, the presence of netilmicin guarantees good antibiotic prophylaxis during the wound repair process.
本研究旨在探讨一种除抗生素奈替米星外还含有透明质酸钠和黄原胶的眼科凝胶在治疗外伤性角膜擦伤中的效果。
外伤性角膜擦伤患者随机接受如下治疗：A组（n = 20），采用封闭包扎12小时，外加一滴含0.15%透明质酸钠、1%黄原胶和0.3%奈替米星的眼凝胶，每日4次，持续5天；B组（n = 20），采用封闭包扎2 - 3天，外加每日4次应用0.3%奈替米星眼膏，持续5天。所有患者在第3天和第7天后通过裂隙灯检查、荧光素染色和角膜缺损拍照进行评估，以评估角膜再上皮化情况。还评估了结膜充血、眼睑水肿、主观不适症状和结膜拭子。
治疗3天后，两组在角膜愈合程度方面未观察到统计学上的显著差异。两种治疗在降低糜烂评分和结膜充血方面也都非常有效（分别为P < 0.0001，P < 0.005），两种治疗类型之间无任何显著差异。还评估了主观不适症状和结膜拭子。
在治疗外伤性角膜擦伤时，给予含透明质酸钠和黄原胶的眼凝胶能够缩短封闭包扎的时间。此外，奈替米星的存在保证了伤口修复过程中有良好的抗生素预防作用。
