Kocatürk Tolga, Gençgönül Ataman, Balica Faruk, Özbağcivan Mehmet, Çakmak Harun
Department of Ophthalmology, Faculty of Medicine, Adnan Menderes University, Aydın, Turkey.
Department of Ophthalmology, Mevki Military Hospital, Ankara, Turkey.
Clin Ophthalmol. 2015 Aug 13;9:1463-6. doi: 10.2147/OPTH.S85638. eCollection 2015.
The aim of this study is to compare the effectiveness of the ophthalmic gels containing hyaluronate, xanthan gum, and netilmycine with fusidic acid in terms of recovery periods of corneal epithelium in the patients who underwent pterygium surgery.
Patients who underwent pterygium surgery were separated into two groups. Forty patients in group 1 were given eye gel containing sodium hyaluronate, xanthan gum, and netilmycine, and 40 patients in group 2 were given one drop of eye gel containing fusidic acid. The patients in both groups were examined at the 12th, 24th, and 48th hours in the postoperative period by using slit-lamp technique. The subjective complaints of the patients such as pain and stinging, and the recovery periods of the corneal epithelial defect were evaluated comparatively by fluorescein staining.
The mean ages were 26±8 years (range: 18-35) and 24±6 years (range: 18-33) in groups 1 and 2, respectively. The closure period of the corneal epithelial defect was observed as 24±8 hours (range: 16-42) and 36±12 hours (range: 18-48) in groups 1 and 2, respectively. The number of the patients suffering from subjective complaints such as pain and stinging in the first 12 hours was six and 29 in groups 1 and 2, respectively. The difference was significant both clinically and statistically (P=0.001).
Combined eye gel containing hyaluronate, xanthan gum, and netilmycine accelerates the recovery of corneal epithelial defect and reduces the complaints of the patients, when compared to the fusidic acid gel. Combined eye gel should be considered as an option for the treatment of the corneal epithelial defect related with pterygium surgery.
本研究旨在比较含透明质酸盐、黄原胶和奈替米星的眼科凝胶与夫西地酸对翼状胬肉手术后患者角膜上皮恢复期的效果。
将接受翼状胬肉手术的患者分为两组。第1组40例患者给予含透明质酸钠、黄原胶和奈替米星的眼凝胶，第2组40例患者给予1滴含夫西地酸的眼凝胶。术后第12、24和48小时，使用裂隙灯技术对两组患者进行检查。通过荧光素染色比较评估患者的主观症状如疼痛和刺痛，以及角膜上皮缺损的恢复期。
第1组和第2组的平均年龄分别为26±8岁（范围：18 - 35岁）和24±6岁（范围：18 - 33岁）。第1组和第2组角膜上皮缺损的闭合期分别观察为24±8小时（范围：16 - 42小时）和36±12小时（范围：18 - 48小时）。术后前12小时出现疼痛和刺痛等主观症状的患者数量，第1组为6例，第2组为29例。差异在临床和统计学上均具有显著性（P = 0.001）。
与夫西地酸凝胶相比，含透明质酸盐、黄原胶和奈替米星的联合眼凝胶可加速角膜上皮缺损的恢复并减轻患者的症状。联合眼凝胶应被视为治疗与翼状胬肉手术相关的角膜上皮缺损的一种选择。
