Trucco Matteo, Loeb David
Division of Pediatric Oncology, Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Bunting-Blaustein Cancer Research Building, Room 2M51, 1650 Orleans Street, Baltimore, MD 21231, USA.
Sarcoma. 2012;2012:291705. doi: 10.1155/2012/291705. Epub 2012 May 9.
Sarcomas represent a heterogeneous group of cancers thought to originate from malignant transformation of mesenchymal cells. There is increasing evidence that many, if not all, sarcomas contain within them tumor-initiating, or "cancer stem," cells responsible for the initiation, maintenance, and potentially relapse and metastasis of the tumor. Various techniques have been adopted in recent years to identify putative sarcoma stem cell populations. The goal of this paper is to summarize the criteria used to identify a stem cell population, describe the more prominent markers and techniques used to isolate cancer stem cells in sarcomas, and review the evidence for the existence of cancer stem cells in sarcomas.
肉瘤是一组异质性癌症，被认为起源于间充质细胞的恶性转化。越来越多的证据表明，即便不是所有的肉瘤，许多肉瘤都含有肿瘤起始细胞或“癌症干细胞”，这些细胞负责肿瘤的起始、维持，以及可能的复发和转移。近年来，人们采用了各种技术来鉴定假定的肉瘤干细胞群体。本文的目的是总结用于鉴定干细胞群体的标准，描述用于分离肉瘤中癌症干细胞的更突出的标志物和技术，并综述肉瘤中存在癌症干细胞的证据。
