Zindancı Ilkin, Albayrak Ozlem, Kavala Mukaddes, Kocaturk Emek, Can Burce, Sudogan Sibel, Koç Melek
Department of Dermatology, Goztepe Training and Research Hospital, Istanbul, Turkey.
ScientificWorldJournal. 2012;2012:312463. doi: 10.1100/2012/312463. Epub 2012 Apr 24.
Psoriasis is a chronic inflammatory skin disorder in which proinflammatory cytokines including IL-6 and TNF-α increase both locally and systematically. It is thought that chronic inflammation results in metabolic diseases and proinflammatory cytokines give rise to the development of atherogenesis, peripheral insulin resistance, hypertension, and type 2 diabetes. Our aim was to investigate the prevalence of metabolic syndrome in patients with psoriasis vulgaris.
Study consisted of 115 plaque-type psoriasis patients and 140 healthy individuals. Data including body weight, height, waist circumference, body-mass index, and arterial blood pressure were collected. Fasting blood glucose, triglyceride, and HDL levels were determined. International Diabetes Federation Criteria for Metabolic Syndrome and Insulin Resistance were used for evaluating patients with metabolic syndrome and diabetes.
Compared to the control group, metabolic syndrome, diabetes mellitus, and hypertension were found to be higher in psoriasis patients. Metabolic syndrome was increased by 3-folds in psoriasis patients and was more prevalent in women than in men. It was determined that the prevalence of metabolic syndrome was higher in psoriasis patients after the age of 40. Metabolic syndrome was not related to smoking, severity of psoriasis, and duration of disease.
Our findings suggest that psoriasis preconditions occurrence of a group of diseases such as diabetes mellitus, hypertension, and metabolic syndrome. For this reason, patients with psoriasis should be treated early and they should be followed with respect to metabolic diseases.
银屑病是一种慢性炎症性皮肤病，其中包括白细胞介素-6和肿瘤坏死因子-α在内的促炎细胞因子在局部和全身均会增加。人们认为慢性炎症会导致代谢性疾病，促炎细胞因子会引发动脉粥样硬化、外周胰岛素抵抗、高血压和2型糖尿病的发生。我们的目的是调查寻常型银屑病患者中代谢综合征的患病率。
研究包括115例斑块型银屑病患者和140名健康个体。收集了包括体重、身高、腰围、体重指数和动脉血压在内的数据。测定了空腹血糖、甘油三酯和高密度脂蛋白水平。采用国际糖尿病联盟代谢综合征和胰岛素抵抗标准对代谢综合征和糖尿病患者进行评估。
与对照组相比，银屑病患者中代谢综合征、糖尿病和高血压的发生率更高。银屑病患者中代谢综合征增加了3倍，且在女性中比男性更普遍。确定40岁以后的银屑病患者中代谢综合征的患病率更高。代谢综合征与吸烟、银屑病严重程度和病程无关。
我们的研究结果表明，银屑病是糖尿病、高血压和代谢综合征等一组疾病发生的先决条件。因此，银屑病患者应尽早接受治疗，并应关注其代谢性疾病。
