银屑病患者代谢综合征及其参数的患病率及其与银屑病病程、严重程度和睡眠质量的相关性：一项横断面研究
Prevalence of Metabolic Syndrome and Its Parameters and Their Correlations With Psoriasis Duration, Severity, and Sleep Quality In Psoriasis Patients: A Cross-Sectional Study.
作者信息
Tas Betul, Kabeloglu Vasfiye
机构信息
Department of Dermatology and Venereology, University of Health Sciences, Istanbul Bagcilar Research and Training Hospital, Istanbul, Turkey.
Department of Neurology, University of Health Sciences, Bakirkoy Prof. Dr. Mazhar Osman Research and Training Hospital, Istanbul, Turkey.
出版信息
Dermatol Pract Concept. 2021 May 20;11(3):e2021049. doi: 10.5826/dpc.1103a49. eCollection 2021 May.
BACKGROUND
Psoriasis is an inflammatory skin disease that may lead to comorbidities, including metabolic syndrome (MS).
OBJECTIVE
We determined the prevalence of MS and its correlation with psoriasis duration, severity, and sleep quality in psoriasis patients.
METHODS
A total of 112 subjects with chronic plaque psoriasis were studied. Demographics, MS parameters, disease duration, severity, and sleep quality were examined. The Psoriasis Area and Severity Index (PASI) and the Pittsburgh Sleep Quality Index (PSQI) were used to assess psoriasis severity and sleep quality, respectively. Presence of MS and its correlations with psoriasis duration, severity and sleep quality were investigated.
RESULTS
Of 112 patients, 76 (67.8%) were diagnosed with MS. Of all patients, 74.1% had a high PASI, and 84.8% had a high PSQI. The mean values of psoriasis duration, body mass index, waist circumference, fasting glucose, HOMA-IR, triglyceride levels, blood pressure, PSQI, sleep latency, and daytime sleep dysfunction were significantly higher in the MS group than non-MS group, whereas the mean HDL level was lower. The prevalences of MS, high fasting glucose, and low HDL were significantly higher among female, but not male, patients with severe psoriasis (PASI >10) than those without severe psoriasis. Disease duration, high body mass index, waist circumference, blood pressure, fasting glucose, HOMA-IR, triglyceride levels, low HDL, and poor sleep quality were significantly correlated with the presence of MS. However, only waist circumference, fasting glucose, blood pressure, and low HDL were predictive of the development of MS.
CONCLUSIONS
MS is common among psoriasis patients, and especially in females with advanced psoriasis, high fasting glucose, and low HDL levels. Besides diagnostic criteria of MS, a long duration of psoriasis, poor sleep quality and high-HOMA-IR correlate with the development of MS. High fasting glucose and low HDL levels may facilitate MS development in association with psoriasis severity in females.
背景
银屑病是一种炎症性皮肤病，可能导致包括代谢综合征（MS）在内的合并症。
目的
我们确定了银屑病患者中MS的患病率及其与银屑病病程、严重程度和睡眠质量的相关性。
方法
共研究了112例慢性斑块状银屑病患者。检查了人口统计学资料、MS参数、疾病病程、严重程度和睡眠质量。分别使用银屑病面积和严重程度指数（PASI）和匹兹堡睡眠质量指数（PSQI）评估银屑病严重程度和睡眠质量。调查了MS的存在及其与银屑病病程、严重程度和睡眠质量的相关性。
结果
112例患者中，76例（67.8%）被诊断为MS。所有患者中，74.1%的PASI较高，84.8%的PSQI较高。MS组的银屑病病程、体重指数、腰围、空腹血糖、HOMA-IR、甘油三酯水平、血压、PSQI、睡眠潜伏期和日间睡眠功能障碍的平均值显著高于非MS组，而平均高密度脂蛋白水平较低。女性重度银屑病（PASI>10）患者中MS、高空腹血糖和低高密度脂蛋白的患病率显著高于非重度银屑病患者，但男性患者并非如此。疾病病程、高体重指数、腰围、血压、空腹血糖、HOMA-IR、甘油三酯水平、低高密度脂蛋白和睡眠质量差与MS的存在显著相关。然而，只有腰围、空腹血糖、血压和低高密度脂蛋白可预测MS的发生。
结论
MS在银屑病患者中很常见，尤其是在患有晚期银屑病、高空腹血糖和低高密度脂蛋白水平的女性中。除了MS的诊断标准外，银屑病病程长、睡眠质量差和高HOMA-IR与MS的发生相关。高空腹血糖和低高密度脂蛋白水平可能与女性银屑病严重程度相关，促进MS的发生。
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