Department of Medicine, Faculty of Medicine, Kuwait University, Jabriya, Kuwait.
Department of Dermatology, Farwaniya Hospital, Ardiya, Kuwait.
Dermatol Ther. 2018 Jan;31(1). doi: 10.1111/dth.12566. Epub 2018 Jan 15.
Association of childhood psoriasis with metabolic syndrome has not been studied well. TNF-alfa contributes to the inflammation seen in metabolic syndrome, and recently etanercept has shown to reduce the levels of inflammatory markers. Assessment of prevalence of metabolic syndrome in juvenile psoriasis patients in Kuwait. We included 236 patients with moderate to severe psoriasis below 18 years treated for at least 24 weeks with TNF inhibitors (Group A), and equal number of age and sex matched cases treated with conventional medications (Group B). The metabolic syndrome (MBS) was defined according to the International Diabetes Foundation (IDF 2007 criteria for children). Increased waist circumference was seen in 56.77% of cases in Group A. Triglyceridemia was less frequent in Group A. MBS was higher in Group B [41·52% vs. 50·42%, odds ratio (OR) 1·76, 95% CI 1.19-2.41; p = .005]. Psoriasis is associated with higher prevalence of metabolic syndrome in children. Six months of anti TNF treatment showed lesser association with metabolic syndrome. With fasting blood glucose, and serum TG seen in significantly lesser number of patients in this group.
儿童期银屑病与代谢综合征的关系尚未得到很好的研究。TNF-α 有助于代谢综合征中出现的炎症，最近依那西普已显示出可降低炎症标志物的水平。评估科威特青少年银屑病患者代谢综合征的患病率。我们纳入了 236 名年龄在 18 岁以下、接受 TNF 抑制剂（A 组）治疗至少 24 周的中重度银屑病患者，以及接受常规药物治疗的年龄和性别匹配病例数相等（B 组）。代谢综合征（MBS）根据国际糖尿病基金会（IDF 2007 年儿童标准）定义。A 组有 56.77%的病例腰围增加。A 组的甘油三酯血症较少见。B 组的 MBS 更高[41.52%比 50.42%，比值比（OR）1.76，95%置信区间（CI）1.19-2.41；p=0.005]。银屑病与儿童代谢综合征的患病率较高相关。抗 TNF 治疗 6 个月与代谢综合征的相关性较小。该组患者的空腹血糖和血清 TG 明显较少。
