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黄芩苷在大鼠体内的代谢及代谢产物的生物学活性。

The metabolism of baicalin in rat and the biological activities of the metabolites.

机构信息

Department of Natural Products Chemistry, Shenyang Pharmaceutical University, Liaoing 110016, China.

出版信息

Evid Based Complement Alternat Med. 2012;2012:404529. doi: 10.1155/2012/404529. Epub 2012 May 13.

DOI:10.1155/2012/404529
PMID:22654953
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3359663/
Abstract

Baicalin is one of the major bioactive constituents of Scutellariae Radix, but the biotransformation of it is poorly understood. In this paper, the metabolism of baicalin in rat was studied. Nine metabolites including one new compound were isolated and identified structurally. The plausible scheme for the biotransformation pathways of baicalin in the rats was deduced. And the main metabolites were evaluated for their antioxidation and anti-inflammation biological activities for the first time.

摘要

黄芩苷是黄芩的主要生物活性成分之一，但对其生物转化知之甚少。本文研究了黄芩苷在大鼠体内的代谢情况。分离并鉴定了 9 种代谢产物，包括 1 种新化合物。推断了黄芩苷在大鼠体内的生物转化途径。并首次评价了主要代谢产物的抗氧化和抗炎生物活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68e8/3359663/9bddc5cd691f/ECAM2012-404529.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68e8/3359663/40bdad7744d0/ECAM2012-404529.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68e8/3359663/d9c653e54400/ECAM2012-404529.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68e8/3359663/b036705de25c/ECAM2012-404529.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68e8/3359663/9bddc5cd691f/ECAM2012-404529.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68e8/3359663/40bdad7744d0/ECAM2012-404529.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68e8/3359663/d9c653e54400/ECAM2012-404529.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68e8/3359663/b036705de25c/ECAM2012-404529.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/68e8/3359663/9bddc5cd691f/ECAM2012-404529.004.jpg

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本文引用的文献

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[Study on the metabolism of the precipitation of Xiexin decoction in rats I].[泻心汤沉淀在大鼠体内的代谢研究I]
Zhongguo Zhong Yao Za Zhi. 2005 Nov;30(21):1673-6.
2
Comparison of the metabolism of baicalin in rats orally administered with Radix scutellariae extract and Shuang-Huang-Lian extract.口服黄芩提取物和双黄连提取物的大鼠中黄芩苷代谢的比较。
Chem Pharm Bull (Tokyo). 2005 Aug;53(8):978-83. doi: 10.1248/cpb.53.978.
3
Pharmacokinetic study on the multi-constituents of Huangqin-Tang decoction in rats.黄芩汤水煎剂多成分在大鼠体内的药代动力学研究
Avicenna J Phytomed. 2024 Jan-Feb;14(1):23-49. doi: 10.22038/AJP.2023.22307.
4
Antiviral Properties of Baicalin: a Concise Review.黄芩苷的抗病毒特性：简要综述
Rev Bras Farmacogn. 2021;31(4):408-419. doi: 10.1007/s43450-021-00182-1. Epub 2021 Oct 6.
5
Regulatory Mechanisms of Baicalin in Cardiovascular Diseases: A Review.黄芩苷在心血管疾病中的调节机制：综述
Front Pharmacol. 2020 Nov 2;11:583200. doi: 10.3389/fphar.2020.583200. eCollection 2020.
6
Pharmacokinetics and Bioavailability Enhancement of Baicalin: A Review.黄芩苷的药代动力学与生物利用度提高：综述
Eur J Drug Metab Pharmacokinet. 2019 Apr;44(2):159-168. doi: 10.1007/s13318-018-0509-3.
7
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J Pharm Pharmacol. 2000 Dec;52(12):1563-8. doi: 10.1211/0022357001777621.