Sirio-Libanés Hospital, Department of Neurology, School of Medicine, University of Buenos Aires (UBA), Buenos Aires, Argentina.
Diabetes Res Clin Pract. 2012 Oct;98(1):68-74. doi: 10.1016/j.diabres.2012.05.013. Epub 2012 Jun 2.
To evaluate the cognitive performance of a homogeneous population of Alzheimer's disease (AD), non-demented Type 2 Diabetes Mellitus (DIAB), demented with concomitant diseases (AD+DIAB) and healthy control subjects. AD is a progressive dementia disorder characterized clinically by impairment of memory, cognition and behavior. Recently, a major research interest in AD has been placed on early evaluation. Diabetes is one of the clinical conditions that represent the greatest risk of developing oxidative stress and dementia. Glucose overload, leading to the development of impaired-induced insulin secretion in DIAB and has been suggested to slow or deter AD pathogenesis.
The degree of cognitive impairment was determined on the Alzheimer Disease Assessment Scale-Cognitive (ADAS-Cog) and the Folstein's Mini Mental State Examination (MMSE); the severity of dementia was quantified applying the Clinical Dementia Rating (CDR) test; the Hamilton test was employed to evaluate depressive conditions; the final population studied was 101 subjects.
The cognitive deterioration is statistically significantly lower (p<0.05) in AD+DIAB patients as compared with AD patients.
In this longitudinal study the superimposed diabetic condition was associated with a lower rate of cognitive decline, while diabetic non-demented patients and controls present normal scores.
评估一组同质的阿尔茨海默病（AD）、非痴呆 2 型糖尿病（DIAB）、伴有合并症的痴呆（AD+DIAB）和健康对照组的认知表现。AD 是一种进行性痴呆障碍，临床上以记忆、认知和行为受损为特征。最近，AD 的早期评估成为一个主要的研究热点。糖尿病是发生氧化应激和痴呆的最大风险之一。葡萄糖过载导致 DIAB 中胰岛素分泌受损，有人认为这会减缓或阻止 AD 的发病机制。
使用阿尔茨海默病评估量表-认知（ADAS-Cog）和福氏简易精神状态检查（MMSE）确定认知障碍程度；使用临床痴呆评定量表（CDR）测试量化痴呆严重程度；使用汉密尔顿抑郁量表评估抑郁状况；最终研究人群为 101 例受试者。
与 AD 患者相比，AD+DIAB 患者的认知功能下降程度显著降低（p<0.05）。
在这项纵向研究中，叠加的糖尿病状态与认知衰退率降低相关，而糖尿病非痴呆患者和对照组的评分正常。
