相似文献
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An essential role of the transcription factor GATA-3 for the function of regulatory T cells.转录因子 GATA-3 对于调节性 T 细胞功能的重要作用。
Immunity. 2011 Sep 23;35(3):337-48. doi: 10.1016/j.immuni.2011.08.012. Epub 2011 Sep 15.
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Expansion of CD4(+) CD25(+) and CD25(-) T-Bet, GATA-3, Foxp3 and RORγt cells in allergic inflammation, local lung distribution and chemokine gene expression.在过敏炎症、肺部局部分布和趋化因子基因表达中，CD4(+)CD25(+)和 CD25(-)T-Bet、GATA-3、Foxp3 和 RORγt 细胞的扩增。
PLoS One. 2011;6(5):e19889. doi: 10.1371/journal.pone.0019889. Epub 2011 May 19.
3
Dynamic expression of transcription factors T-bet and GATA-3 by regulatory T cells maintains immunotolerance.调节性T细胞中转录因子T-bet和GATA-3的动态表达维持免疫耐受。
Nat Immunol. 2015 Feb;16(2):197-206. doi: 10.1038/ni.3053. Epub 2014 Dec 15.
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An intrinsic mechanism predisposes Foxp3-expressing regulatory T cells to Th2 conversion in vivo.体内固有机制使 Foxp3 表达的调节性 T 细胞易于向 Th2 转化。
J Immunol. 2010 Nov 15;185(10):5983-92. doi: 10.4049/jimmunol.1001255. Epub 2010 Oct 13.
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A Mutation in the Transcription Factor Foxp3 Drives T Helper 2 Effector Function in Regulatory T Cells.转录因子 Foxp3 中的一个突变驱动调节性 T 细胞中的辅助性 T 细胞 2 效应功能。
Immunity. 2019 Feb 19;50(2):362-377.e6. doi: 10.1016/j.immuni.2018.12.016. Epub 2019 Jan 29.
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The transcriptional repressor Bcl6 controls the stability of regulatory T cells by intrinsic and extrinsic pathways.转录抑制因子Bcl6通过内在和外在途径控制调节性T细胞的稳定性。
Immunology. 2015 May;145(1):11-23. doi: 10.1111/imm.12393.
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The Foxp3+ regulatory T-cell population requires IL-4Rα signaling to control inflammation during helminth infections.Foxp3+ 调节性 T 细胞群体需要 IL-4Rα 信号来控制寄生虫感染期间的炎症。
PLoS Biol. 2018 Oct 31;16(10):e2005850. doi: 10.1371/journal.pbio.2005850. eCollection 2018 Oct.
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GATA3-driven Th2 responses inhibit TGF-beta1-induced FOXP3 expression and the formation of regulatory T cells.由GATA3驱动的Th2反应会抑制转化生长因子β1（TGF-β1）诱导的叉头盒蛋白P3（FOXP3）表达以及调节性T细胞的形成。
PLoS Biol. 2007 Dec;5(12):e329. doi: 10.1371/journal.pbio.0050329.
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The expression levels of transcription factors T-bet, GATA-3, RORγt and FOXP3 in peripheral blood lymphocyte (PBL) of patients with liver cancer and their significance.肝癌患者外周血淋巴细胞（PBL）中转录因子T-bet、GATA-3、RORγt和FOXP3的表达水平及其意义。
Int J Med Sci. 2015 Jan 1;12(1):7-16. doi: 10.7150/ijms.8352. eCollection 2015.
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Suppressive IL-17AFoxp3 and ex-Th17 IL-17AFoxp3 T cells are a source of tumour-associated T cells.抑制性的 IL-17A+Foxp3+ 和前 Th17 细胞 IL-17A+Foxp3+T 细胞是肿瘤相关 T 细胞的来源。
Nat Commun. 2017 Mar 14;8:14649. doi: 10.1038/ncomms14649.
引用本文的文献
1
Integration of genome and transcriptome reveals core genes and allele-specific expression genetic variants associated with immune differentiation of taurine ancestry dairy cattle from indicine ancestry cattle.基因组与转录组整合揭示了与瘤牛血统奶牛和印度瘤牛血统奶牛免疫分化相关的核心基因及等位基因特异性表达遗传变异。
BMC Genomics. 2025 Aug 27;26(1):778. doi: 10.1186/s12864-025-11936-9.
2
Regulatory T cell therapy promotes TGF-β and IL-6-dependent pro-inflammatory Th17 cell generation by reducing IL-2.调节性T细胞疗法通过降低白细胞介素-2来促进转化生长因子-β和白细胞介素-6依赖性促炎性辅助性T细胞17的生成。
Nat Commun. 2025 Aug 16;16(1):7644. doi: 10.1038/s41467-025-62628-7.
3
Regulatory T cells epigenetically reprogrammed from autoreactive effector T cells mitigate established autoimmunity.从自身反应性效应T细胞经表观遗传重编程而来的调节性T细胞可减轻已确立的自身免疫。
bioRxiv. 2025 Jul 28:2025.07.24.665398. doi: 10.1101/2025.07.24.665398.
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GATA3 regulates Th1/Th2 balance in allergic rhinitis by interacting with RUNX1.GATA3通过与RUNX1相互作用来调节变应性鼻炎中的Th1/Th2平衡。
Future Sci OA. 2025 Dec;11(1):2541503. doi: 10.1080/20565623.2025.2541503. Epub 2025 Aug 1.
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The silence within: a conserved intragenic silencing element governs HTLV-1 expression via host RUNX1 complex binding.内部沉默：一种保守的基因内沉默元件通过与宿主RUNX1复合体结合来调控HTLV-1的表达。
Npj Viruses. 2025 Jul 23;3(1):58. doi: 10.1038/s44298-025-00136-7.
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Activity-attenuated serum albumin-fused interleukin-33 suppresses experimental autoimmune encephalomyelitis.活性减弱的血清白蛋白融合白细胞介素-33可抑制实验性自身免疫性脑脊髓炎。
Cell Rep Med. 2025 Jul 15;6(7):102231. doi: 10.1016/j.xcrm.2025.102231. Epub 2025 Jul 7.
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Dairy Propionibacteria: Probiotic Properties and Their Molecular Bases.乳制品丙酸杆菌：益生菌特性及其分子基础
Biomolecules. 2025 Jun 17;15(6):886. doi: 10.3390/biom15060886.
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Immunological pathogenesis of inflammatory bowel disease: focus on tissue resident memory T cells.炎症性肠病的免疫发病机制：聚焦于组织驻留记忆T细胞。
Front Immunol. 2025 Jun 3;16:1591584. doi: 10.3389/fimmu.2025.1591584. eCollection 2025.
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Experimental autoimmune encephalomyelitis impairs the immunomodulatory effects of mesenchymal stem cells on splenocyte responses.实验性自身免疫性脑脊髓炎损害间充质干细胞对脾细胞反应的免疫调节作用。
Mol Biol Rep. 2025 Jun 11;52(1):582. doi: 10.1007/s11033-025-10684-z.
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Integration of single-cell and bulk RNA sequencing identifies and validates T cell-related prognostic model in hepatocellular carcinoma.单细胞和批量RNA测序的整合鉴定并验证了肝细胞癌中与T细胞相关的预后模型。
PLoS One. 2025 May 2;20(5):e0322706. doi: 10.1371/journal.pone.0322706. eCollection 2025.
本文引用的文献
1
Foxo transcription factors control regulatory T cell development and function.Foxo 转录因子控制调节性 T 细胞的发育和功能。
Immunity. 2010 Dec 14;33(6):890-904. doi: 10.1016/j.immuni.2010.12.002.
2
Stability of the regulatory T cell lineage in vivo.体内调节性 T 细胞谱系的稳定性。
Science. 2010 Sep 24;329(5999):1667-71. doi: 10.1126/science.1191996.
3
Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells.Foxo 蛋白协同控制 Foxp3+调节性 T 细胞的分化。
Nat Immunol. 2010 Jul;11(7):618-27. doi: 10.1038/ni.1884. Epub 2010 May 13.
4
Prediction of regulatory transcription factors in T helper cell differentiation and maintenance.辅助性T细胞分化与维持过程中调控转录因子的预测
Genome Inform. 2010 Jan;22:84-94.
5
Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate.调控性 T 细胞命运中 Foxp3 基因中保守非编码 DNA 元件的作用。
Nature. 2010 Feb 11;463(7282):808-12. doi: 10.1038/nature08750. Epub 2010 Jan 13.
6
Nuclear factor-kappaB modulates regulatory T cell development by directly regulating expression of Foxp3 transcription factor.核因子-κB 通过直接调节 Foxp3 转录因子的表达来调节调节性 T 细胞的发育。
Immunity. 2009 Dec 18;31(6):921-31. doi: 10.1016/j.immuni.2009.09.022.
7
Cutting edge: the Th1 response inhibits the generation of peripheral regulatory T cells.前沿：Th1 反应抑制外周调节性 T 细胞的产生。
J Immunol. 2010 Jan 1;184(1):30-4. doi: 10.4049/jimmunol.0903412. Epub 2009 Nov 30.
8
Decrease of Foxp3+ Treg cell number and acquisition of effector cell phenotype during lethal infection.致死性感染期间Foxp3 +调节性T细胞数量减少及效应细胞表型的获得。
Immunity. 2009 Nov 20;31(5):772-86. doi: 10.1016/j.immuni.2009.10.001. Epub 2009 Nov 5.
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Indispensable role of the Runx1-Cbfbeta transcription complex for in vivo-suppressive function of FoxP3+ regulatory T cells.Runx1-Cbfbeta转录复合体对FoxP3 +调节性T细胞体内抑制功能的不可或缺作用。
Immunity. 2009 Oct 16;31(4):609-20. doi: 10.1016/j.immuni.2009.09.003. Epub 2009 Oct 1.
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CD4+ regulatory T cells control TH17 responses in a Stat3-dependent manner.CD4+ 调节性 T 细胞通过 Stat3 依赖性方式控制 TH17 反应。
Science. 2009 Nov 13;326(5955):986-91. doi: 10.1126/science.1172702. Epub 2009 Oct 1.
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