内侧杏仁核内注射蛋白激酶 Mzeta 抑制剂 ZIP 破坏前景背景恐惧记忆。
Intra-amygdala infusion of the protein kinase Mzeta inhibitor ZIP disrupts foreground context fear memory.
机构信息
Department of Psychology, University of Wisconsin-Milwaukee, 2441 Hartford Ave., Milwaukee, WI 53211, USA.
出版信息
Neurobiol Learn Mem. 2012 Sep;98(2):148-53. doi: 10.1016/j.nlm.2012.05.003. Epub 2012 May 31.
Abstract
Protein kinase Mzeta has been the subject of much recent interest, as it is the only molecule currently identified to maintain memory. Despite the wealth of studies investigating PKMζ in memory, questions remain about which types of memory PKMζ supports. Further, it is unclear how long the inhibitor of PKMz, ζ-pseudosubstrate inhibitory peptide (ZIP) remains in the brain after infusion. Here, we demonstrate that foreground context fear memory requires PKMζ activity in the amygdala. We also show that ZIP is fully cleared from the brain by 24h after infusion. These data contribute to a growing body of literature that demonstrates that PKMζ plays a key role in maintaining amygdala-dependent memory and provides new information about the degradation timecourse of the most commonly used inhibitor of PKMζ, ZIP.
摘要
蛋白激酶 Mzeta 是近来备受关注的焦点，因为它是目前唯一被确定能维持记忆的分子。尽管有大量研究调查 PKMζ 在记忆中的作用，但仍存在一些问题，例如 PKMζ 支持哪种类型的记忆。此外，PKMz 抑制剂 ζ-假底物抑制肽（ZIP）在脑内输注后能持续多长时间尚不清楚。在这里，我们证明了前景上下文恐惧记忆需要杏仁核中的 PKMζ 活性。我们还表明，ZIP 在输注后 24 小时内从大脑中完全清除。这些数据为越来越多的文献提供了支持，证明了 PKMζ 在维持杏仁核依赖性记忆中起着关键作用，并提供了有关最常用的 PKMζ 抑制剂 ZIP 的降解时程的新信息。
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本文引用的文献
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