Kwapis Janine L, Jarome Timothy J, Lonergan Mary E, Helmstetter Fred J
University of Wisconsin-Milwaukee, Milwaukee, WI 53211, USA.
Behav Neurosci. 2009 Aug;123(4):844-50. doi: 10.1037/a0016343.
Recent work on the long-term stability of memory and synaptic plasticity has identified a potentially critical role for protein kinase Mzeta (PKMzeta). PKMzeta is a constitutively active, atypical isoform of protein kinase C that is believed to maintain long term potentiation at hippocampal synapses in vitro. In behaving animals, local inhibition of PKMzeta disrupts spatial memory in the hippocampus and conditioned taste aversion memory in the insular cortex. The role of PKMzeta in context fear memory is less clear. This study examined the role of PKMzeta in amygdala and hippocampal neurons following a standard fear conditioning protocol. The results indicate that PKMzeta inhibition in the amygdala, but not in the hippocampus, can disrupt fear memory. This suggests that PKMzeta may only maintain select forms of memory in specific brain structures and does not participate in a universal memory storage mechanism.
近期关于记忆长期稳定性和突触可塑性的研究确定了蛋白激酶Mζ（PKMzeta）可能发挥的关键作用。PKMzeta是蛋白激酶C的一种组成型激活的非典型亚型，据信它能在体外维持海马体突触的长时程增强。在行为动物中，局部抑制PKMzeta会破坏海马体中的空间记忆以及岛叶皮质中的条件性味觉厌恶记忆。PKMzeta在情境恐惧记忆中的作用尚不清楚。本研究采用标准恐惧条件反射方案，研究了PKMzeta在杏仁核和海马神经元中的作用。结果表明，抑制杏仁核中的PKMzeta会破坏恐惧记忆，但抑制海马体中的PKMzeta则不会。这表明PKMzeta可能仅在特定脑区维持特定形式的记忆，并不参与通用的记忆存储机制。
