Department of Breast Surgery, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
Arch Med Sci. 2012 May 9;8(2):303-9. doi: 10.5114/aoms.2012.28558.
To screen the risk factors associated with breast cancer among Chinese women in order to evaluate the individual risk of developing breast cancer among women in China.
A case-control study on 416 breast cancer patients and 1156 matched controls was conducted in 14 hospitals in 8 provinces of China in 2008. Controls were age- and region-matched to the cases. Clinicians conducted in-person interviews with the subjects to collect information on demographics and suspected risk factors for breast cancer that are known worldwide. Conditional logistic regression was used to derive odds ratios (OR) and 95% confidence intervals (CI) for the associations between risk factors and breast cancer.
Compared with matched controls, women with breast cancer were significantly more likely to have higher body mass index (BMI, OR = 4.07, 95% CI: 2.98-5.55), history of benign breast disease (BBD) biopsy (OR = 1.68, 95% CI: 1.19-2.38), older age of menarche (AOM) (OR = 1.41, 95% CI: 1.07-1.87), stress anticipation (SA), for grade 1-4, OR = 2.15, 95% CI: 1.26-3.66; for grade 5-9, OR = 3.48, 95% CI: 2.03-5.95) and menopause (OR = 2.22, 95% CI: 1.50-3.282) at the level of p < 0.05. Family history of breast cancer (FHBC) in first-degree relatives (OR = 1.66, 95% CI: 0.77-3.59) and use of oral contraceptives (OC) (OR = 1.59, 95% CI: 0.83-3.05) were associated with an increased risk of breast cancer at the level of p < 0.20.
Our results showed that BMI, history of BBD biopsy, older AOM, SA and menopause were associated with increased risk of breast cancer among Chinese women. The findings derived from the study provided some suggestions for population-based prevention and control of breast cancer in China.
为了筛选中国女性乳腺癌的相关风险因素，从而评估中国女性患乳腺癌的个体风险。
2008 年，我们在全国 8 个省的 14 家医院进行了一项病例对照研究，共纳入 416 例乳腺癌患者和 1156 名匹配对照。对照与病例在年龄和地区上相匹配。临床医生通过面对面访谈收集了与乳腺癌相关的人口统计学和可疑风险因素的信息，这些因素在全球范围内都是已知的。采用条件 logistic 回归计算风险因素与乳腺癌之间关联的比值比（OR）和 95%置信区间（CI）。
与匹配对照相比，乳腺癌患者的体质指数（BMI）更高（OR=4.07，95%CI：2.98-5.55）、有良性乳腺疾病（BBD）活检史（OR=1.68，95%CI：1.19-2.38）、初潮年龄较大（AOM）（OR=1.41，95%CI：1.07-1.87）、压力预期（SA）为 1-4 级（OR=2.15，95%CI：1.26-3.66）；5-9 级（OR=3.48，95%CI：2.03-5.95）和绝经（OR=2.22，95%CI：1.50-3.28）的比例更高（p<0.05）。一级亲属乳腺癌家族史（FHBC）（OR=1.66，95%CI：0.77-3.59）和口服避孕药（OC）的使用（OR=1.59，95%CI：0.83-3.05）与乳腺癌风险增加相关（p<0.20）。
我们的结果表明，BMI、BBD 活检史、初潮年龄较大、SA 和绝经与中国女性乳腺癌风险增加相关。本研究结果为中国开展乳腺癌的人群防治工作提供了一定的参考依据。
