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评估一种用于检测溶组织内阿米巴的即时粪便抗原检测试验。

Evaluation of a rapid point-of-care fecal antigen detection test for Entamoeba histolytica.

机构信息

Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, VA 22908-1337, USA.

出版信息

Am J Trop Med Hyg. 2012 Jun;86(6):980-1. doi: 10.4269/ajtmh.2012.11-0661.

DOI:10.4269/ajtmh.2012.11-0661
PMID:22665604
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3366543/
Abstract

Amebiasis is a major cause of morbidity and mortality in the developing world. A reliable point-of-care test would help to improve diagnosis and early treatment. We evaluated a novel rapid fecal antigen detection test for E. histolytica (E. HISTOLYTICA QUIK CHEK; TechLab, Inc., Blacksburg, VA), in a cohort of children in Bangladesh where amebiasis is endemic. This point-of-care test had a sensitivity of 100% and a specificity of 100% when compared with enzyme-linked immunosorbent assay antigen detection.

摘要

阿米巴病是发展中国家发病率和死亡率的主要原因。一种可靠的即时检测方法将有助于改善诊断和早期治疗。我们在孟加拉国的一个阿米巴病流行的儿童队列中评估了一种新的快速粪便抗原检测技术(TechLab,弗吉尼亚州布莱克斯堡的 E. histolytica [E. HISTOLYTICA QUIK CHEK])。与酶联免疫吸附试验抗原检测相比,该即时检测方法的敏感性为 100%,特异性为 100%。

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本文引用的文献

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Evaluation of Entamoeba histolytica antigen and antibody point-of-care tests for the rapid diagnosis of amebiasis.评估溶组织内阿米巴抗原和抗体即时检验用于阿米巴病的快速诊断
J Clin Microbiol. 2006 Dec;44(12):4569-71. doi: 10.1128/JCM.01979-06. Epub 2006 Oct 11.
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Real-time-PCR assay for diagnosis of Entamoeba histolytica infection.用于诊断溶组织内阿米巴感染的实时荧光定量聚合酶链反应检测法
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Amebiasis.阿米巴病
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J Clin Microbiol. 2000 Sep;38(9):3235-9. doi: 10.1128/JCM.38.9.3235-3239.2000.
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Monoclonal antibodies directed against the galactose-binding lectin of Entamoeba histolytica enhance adherence.针对溶组织内阿米巴半乳糖结合凝集素的单克隆抗体可增强黏附作用。
J Immunol. 1990 Jun 15;144(12):4803-9.