对与南美洲野火病相关的接吻虫 Triatoma matogrossensis 的唾液转录组的深入了解。
An insight into the sialotranscriptome of Triatoma matogrossensis, a kissing bug associated with fogo selvagem in South America.
机构信息
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20892, USA.
出版信息
Am J Trop Med Hyg. 2012 Jun;86(6):1005-14. doi: 10.4269/ajtmh.2012.11-0690.
Abstract
Triatoma matogrossensis is a Hemiptera that belongs to the oliveirai complex, a vector of Chagas' disease that feeds on vertebrate blood in all life stages. Hematophagous insects' salivary glands (SGs) produce potent pharmacologic compounds that counteract host hemostasis, including anticlotting, antiplatelet, and vasodilatory molecules. Exposure to T. matogrossensis was also found to be a risk factor associated with the endemic form of the autoimmune skin disease pemphigus foliaceus, which is described in the same regions where Chagas' disease is observed in Brazil. To obtain a further insight into the salivary biochemical and pharmacologic diversity of this kissing bug and to identify possible allergens that might be associated with this autoimmune disease, a cDNA library from its SGs was randomly sequenced. We present the analysis of a set of 2,230 (SG) cDNA sequences, 1,182 of which coded for proteins of a putative secretory nature.
摘要
大褐蛉属 Triatoma matogrossensis 是半翅目昆虫，属于 oliveirai 复合物，是一种传播克氏锥虫病的载体，在所有生命阶段都以脊椎动物的血液为食。吸血昆虫的唾液腺 (SG) 会产生强效的药理化合物，以对抗宿主的止血作用，包括抗凝血、抗血小板和血管扩张分子。接触大褐蛉属 Triatoma matogrossensis 也被发现是与自身免疫性皮肤病落叶性天疱疮地方性流行形式相关的一个风险因素，这种皮肤病在巴西与克氏锥虫病观察到的地区相同。为了更深入地了解这种接吻虫的唾液生化和药理多样性，并确定可能与这种自身免疫性疾病相关的潜在过敏原，我们对其 SG 的 cDNA 文库进行了随机测序。我们呈现了对一组 2230 个 (SG) cDNA 序列的分析，其中 1182 个编码具有潜在分泌性质的蛋白质。
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