[石松生物碱的化学成分研究]
[Study on chemical constituents of Lycopodium alkaloids].
作者信息
Liu Huijie, Wang Ye
机构信息
The Key Laboratory for Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002, China.
出版信息
Zhongguo Zhong Yao Za Zhi. 2012 Feb;37(4):475-7.
OBJECTIVE
To study the alkaloid chemical constituents of Lycopodium japonicum.
METHOD
Compounds were isolated and purified by such methods as silica gel column chromatography, RP-C18 reversed phase column chromatography, Sephadex LH-20 column chromatography and Waters semi-preparative liquid chromatogram, and their structures were identified based on physicochemical property and spectrum data.
RESULT
Nine known alkaloid chemical constituents were isolated and identified, they were lycodoline (1), lucidioline (2), alpha-obscurine (3), lycopodine (4), lycoposerramine-L (5), lycoposerramine-M (6), 11alpha-O-acetyl-lycopodine (7), des-N-methyl-a-obscurine (8), clavolonine (9).
CONCLUSION
Compounds 4-9 were obtained from L. japonicum for the first time.
目的
研究石松的生物碱化学成分。
方法
采用硅胶柱色谱、RP-C18反相柱色谱、Sephadex LH-20柱色谱和Waters半制备液相色谱等方法对化合物进行分离纯化，并根据其理化性质和光谱数据鉴定其结构。
结果
分离鉴定出9种已知生物碱化学成分，分别为石松灵碱（1）、石松定碱（2）、α-光石松碱（3）、石松碱（4）、石松胺-L（5）、石松胺-M（6）、11α-O-乙酰石松碱（7）、去-N-甲基-α-光石松碱（8）、棒石松宁碱（9）。
结论
化合物4-9首次从石松中获得。
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