Department of Biotechnical Cosmetology, Cheng Shiu University, Kaohsiung, Taiwan.
Qual Life Res. 2013 May;22(4):715-23. doi: 10.1007/s11136-012-0213-8. Epub 2012 Jun 6.
Pretreatment quality of life (QoL) has been used to predict survival in cancer patients. In this study, we examined the prognostic value of QoL measured after treatment on subsequent survival in patients with nasopharyngeal carcinoma (NPC).
We enrolled 273 patients with NPC who had been curatively treated for more than 1 year. The EORTC QLQ-C30 and H&N35 questionnaires were completed 1 year after radiotherapy. The predictability of QoL variables on disease-specific survival (DSS) and overall survival (OS) was analyzed using Cox's proportional hazards models.
Twenty-nine (10.6%) patients developed locoregional relapse and 27 (9.9%) had distant metastasis after the QoL survey with subsequent 5-year DSS and OS rates of 87.9% and 84.0 %, respectively. Based on the QLQ-C30, scales of physical functioning, fatigue, and appetite loss significantly predicted DSS and OS (p < 0.05). In the H&N35, only sexuality was significantly correlated with DSS and OS (p < 0.05). An increment of 10 points in physical functioning (HR: 0.69; 95% CI: 0.48-0.90; p = 0.004) or a decline of 10 points in fatigue problems (HR: 1.40; 95% CI: 1.19-1.61; p = 0.0002), appetite loss (HR: 1.21; 95% CI: 1.03-1.40; p = 0.02), and sexuality (HR: 1.14; 95% CI: 1.02-1.25; p = 0.019) was associated with better OS.
Some QoL variables measured after the treatment provide prognostic value on subsequent survival in patients with NPC.
生活质量（QoL）的预处理已被用于预测癌症患者的生存。在这项研究中，我们检查了 NPC 患者治疗后 QoL 测量对随后生存的预后价值。
我们招募了 273 名接受根治性治疗超过 1 年的 NPC 患者。在放疗后 1 年内完成了 EORTC QLQ-C30 和 H&N35 问卷。使用 Cox 比例风险模型分析 QoL 变量对疾病特异性生存（DSS）和总生存（OS）的预测能力。
在 QoL 调查后，29 例（10.6%）患者发生局部区域复发，27 例（9.9%）发生远处转移，随后 5 年 DSS 和 OS 率分别为 87.9%和 84.0%。基于 QLQ-C30，身体功能、疲劳和食欲丧失量表显著预测 DSS 和 OS（p < 0.05）。在 H&N35 中，只有性功能与 DSS 和 OS 显著相关（p < 0.05）。身体功能增加 10 分（HR：0.69；95%CI：0.48-0.90；p = 0.004）或疲劳问题减少 10 分（HR：1.40；95%CI：1.19-1.61；p = 0.0002）、食欲丧失（HR：1.21；95%CI：1.03-1.40；p = 0.02）和性功能（HR：1.14；95%CI：1.02-1.25；p = 0.019）与更好的 OS 相关。
治疗后测量的一些 QoL 变量为 NPC 患者的随后生存提供了预后价值。
