微流控结合外部离子交联制备形状可控的微凝胶颗粒。
Shape controllable microgel particles prepared by microfluidic combining external ionic crosslinking.
机构信息
Hubei Key Laboratory of Materials Chemistry and Service Failure, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074 China.
出版信息
Biomicrofluidics. 2012 Jun;6(2):26502-265029. doi: 10.1063/1.4720396. Epub 2012 May 18.
Abstract
Alginate microgels with varied shapes, such as mushroom-like, hemi-spherical, red blood cell-like, and others, were generated by combining microfluidic and external ionic crosslinking methods. This novel method allows a continuous fine tuning of the microgel particles shape by simply varying the gelation conditions, e.g., viscosity of the gelation bath, collecting height, interfacial tension. The release behavior of iopamidol-loaded alginate microgel particles with varied morphologies shows significant differences. Our technique can also be extended to microgels formation from different anionic biopolymers, providing new opportunities to produce microgels with various anisotropic dimensions for the applications in drug delivery, optical devices, and in advanced materials formation.
摘要
采用微流控和外部离子交联相结合的方法，制备了具有不同形状（如蘑菇状、半球形、红细胞状等）的海藻酸盐微凝胶。该新方法通过简单地改变凝胶化条件（例如凝胶浴的粘度、收集高度、界面张力），可以连续微调微凝胶颗粒的形状。具有不同形态的碘帕醇负载的海藻酸盐微凝胶颗粒的释放行为存在显著差异。我们的技术还可以扩展到不同阴离子生物聚合物的微凝胶形成，为用于药物输送、光学器件和先进材料形成的各向异性尺寸的微凝胶的制备提供了新的机会。
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