Post-Graduate Program in Epidemiology, Pelotas Federal University, Pelotas, Brazil.
J Clin Periodontol. 2012 Aug;39(8):717-24. doi: 10.1111/j.1600-051X.2012.01906.x. Epub 2012 Jun 3.
To evaluate the association between obesity and periodontal disease and the mediating effect of oral hygiene, systemic inflammation and carbohydrate intake.
Subjects born in 1982 in Pelotas, Brazil (n = 5,914), have been followed for several times. Oral health was assessed in a representative sample of 720 individuals at 24 years. Obesity, waist circumference and number of episodes with obesity between 15 and 23 years of age were the main exposures. Mediating effect of oral hygiene, C-reactive protein level and carbohydrate consumption was also assessed.
Obese individuals were more likely to have ≥ 2 teeth with gingival bleeding. However, after adjusting for confounders, the association was not statistically significant [OR (obese × 2 or more teeth) 1.72 (95% CI: 0.95, 3.11)] and adjustment for potential mediators decreased the OR (OR = 1.38). The risk of presenting calculus in obese subjects was 10% higher [PR 1.10 (95% CI: 1.02, 1.18)]. The number of episodes of obesity between 15 and 23 years was associated with dental calculus. Periodontal pockets were not associated with obesity.
Systemic inflammation and oral hygiene may be mediating the association between obesity and gingivitis. Obesity was not associated with periodontal pockets in young adults in this cohort.
评估肥胖与牙周病的相关性，以及口腔卫生、全身炎症和碳水化合物摄入的中介作用。
1982 年出生于巴西佩洛塔斯的受试者（n=5914），随访多次。在 24 岁时对一个具有代表性的 720 人的样本进行了口腔健康评估。肥胖、腰围和 15-23 岁时肥胖发作次数是主要暴露因素。还评估了口腔卫生、C 反应蛋白水平和碳水化合物摄入量的中介作用。
肥胖者更有可能有≥2 颗牙龈出血的牙齿。然而，在调整混杂因素后，相关性无统计学意义[OR（肥胖×2 颗或更多牙齿）1.72（95%CI：0.95，3.11）]，潜在中介物的调整降低了 OR（OR=1.38）。肥胖者出现牙石的风险增加了 10%[PR 1.10（95%CI：1.02，1.18）]。15-23 岁时肥胖发作次数与牙石有关。牙周袋与肥胖无关。
全身炎症和口腔卫生可能介导肥胖与牙龈炎之间的关联。在该队列中，肥胖与年轻人的牙周袋无关。
