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本文引用的文献

1
Asynchronous magnetic bead rotation microviscometer for rapid, sensitive, and label-free studies of bacterial growth and drug sensitivity.异步磁珠旋转微粘度计，用于快速、灵敏、无标记研究细菌生长和药物敏感性。
Anal Chem. 2012 Jun 19;84(12):5250-6. doi: 10.1021/ac300128p. Epub 2012 Jun 1.
2
Asynchronous magnetic bead rotation (AMBR) biosensor in microfluidic droplets for rapid bacterial growth and susceptibility measurements.用于快速细菌生长和药敏测量的微流控液滴中异步磁珠旋转（AMBR）生物传感器。
Lab Chip. 2011 Aug 7;11(15):2604-11. doi: 10.1039/c0lc00734j. Epub 2011 Jun 10.
3
Directed self-assembly of a colloidal kagome lattice.胶体 kagome 晶格的定向自组装。
Nature. 2011 Jan 20;469(7330):381-4. doi: 10.1038/nature09713.
4
High frequency asynchronous magnetic bead rotation for improved biosensors.用于改进生物传感器的高频异步磁珠旋转
Appl Phys Lett. 2010 Nov 29;97(22):223701. doi: 10.1063/1.3505492.
5
Monitoring the growth and drug susceptibility of individual bacteria using asynchronous magnetic bead rotation sensors.使用异步磁珠旋转传感器监测单个细菌的生长和药敏性。
Biosens Bioelectron. 2011 Jan 15;26(5):2751-5. doi: 10.1016/j.bios.2010.10.010. Epub 2010 Oct 14.
6
Antimicrobial susceptibility testing: a review of general principles and contemporary practices.抗菌药物敏感性测试：一般原则和当代实践的综述。
Clin Infect Dis. 2009 Dec 1;49(11):1749-55. doi: 10.1086/647952.
7
Controlled torque on superparamagnetic beads for functional biosensors.用于功能生物传感器的超顺磁性微珠的可控扭矩
Biosens Bioelectron. 2009 Mar 15;24(7):1937-41. doi: 10.1016/j.bios.2008.09.024. Epub 2008 Oct 14.
8
Rapid identification and antimicrobial susceptibility testing reduce antibiotic use and accelerate pathogen-directed antibiotic use.快速鉴定和抗菌药物敏感性测试可减少抗生素使用并加速针对病原体的抗生素使用。
J Antimicrob Chemother. 2008 Feb;61(2):428-35. doi: 10.1093/jac/dkm497. Epub 2007 Dec 21.
9
The relationship between antimicrobial resistance and patient outcomes: mortality, length of hospital stay, and health care costs.抗菌药物耐药性与患者预后之间的关系：死亡率、住院时间和医疗费用。
Clin Infect Dis. 2006 Jan 15;42 Suppl 2:S82-9. doi: 10.1086/499406.
10
Dynamics of disklike clusters formed in a magnetorheological fluid under a rotational magnetic field.旋转磁场作用下磁流变液中形成的盘状团簇的动力学
Phys Rev E Stat Nonlin Soft Matter Phys. 2005 Mar;71(3 Pt 1):032502. doi: 10.1103/PhysRevE.71.032502. Epub 2005 Mar 18.

自组装磁珠生物传感器用于测量细菌生长和抗菌药物敏感性测试。

Self-assembled magnetic bead biosensor for measuring bacterial growth and antimicrobial susceptibility testing.

机构信息

University of Michigan, Department of Chemistry, 930 N. University, Ann Arbor, MI 48109-1055, USA.

出版信息

Small. 2012 Aug 20;8(16):2477-82. doi: 10.1002/smll.201200110. Epub 2012 Jun 5.

DOI:10.1002/smll.201200110
PMID:22674520
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3625966/
Abstract

Bacterial antibiotic resistance is one of the major concerns of modern healthcare worldwide, and the development of rapid, growth-based, antimicrobial susceptibility tests is key for addressing it. The cover image shows a self-assembled asynchronous magnetic bead rotation (AMBR) biosensor developed for rapid detection of bacterial growth. Using the biosensors, the minimum inhibitory concentration of a clinical E. coli isolate can be measured within two hours, where currently tests take 6-24 hours. A 16-well prototype is also constructed for simple and robust observation of the self-assembled AMBR biosensors.

摘要

细菌抗生素耐药性是当今全球医疗保健的主要关注点之一，而快速、基于生长的抗菌药物敏感性测试的发展是解决这一问题的关键。封面图片显示了一种用于快速检测细菌生长的自组装异步磁珠旋转（AMBR）生物传感器。使用该生物传感器，可以在两小时内测量临床大肠杆菌分离株的最小抑菌浓度，而目前的测试需要 6-24 小时。还构建了一个 16 孔原型，用于简单而稳健地观察自组装的 AMBR 生物传感器。