Garcia T, Tourbah A, Setrouk É, Ducasse A, Arndt C
Service d'ophtalmologie, hôpital Robert-Debré, CHU de Reims, avenue du Général-Koenig, 51092 Reims cedex, France.
J Fr Ophtalmol. 2012 Jun;35(6):454-66. doi: 10.1016/j.jfo.2012.02.002. Epub 2012 Jun 5.
Optical coherence tomography (OCT) is a potential tool for diagnosis and follow-up in diseases of the anterior visual pathway in that it provides a reproducible and reliable quantification of retinal nerve fiber layer (RNFL) thickness. A review of the literature was conducted to define the utility of OCT in neuro-ophthalmology.
The clinical applications of RNFL thickness measurement by OCT time domain were analyzed. The PubMed search engine enabled us to select the relevant publications, using the following keywords: "optic neuropathy", "retinal nerve fiber layer thickness", and "optical coherence tomography". Publications concerning glaucoma were excluded from this review.
The course of RNFL thickness depends on the underlying disease: (I) progressive reduction toward atrophy (e.g., optic neuritis, chiasmal compression) or (II) initial increase in RNFL thickness followed by a reduction toward (IIa) normalization (papilledema) or (IIb) atrophy (anterior ischemic optic neuropathy, Leber hereditary optic neuropathy).
Depending on the type of anterior visual pathway impairment, OCT provides RNFL data relevant for diagnosis, follow-up, and prognosis. As in macular disease, OCT has become an important clinical tool for routine disease assessment in neuro-ophthalmology.
光学相干断层扫描（OCT）是一种用于诊断和随访前视觉通路疾病的潜在工具，因为它能对视网膜神经纤维层（RNFL）厚度进行可重复且可靠的量化。我们对文献进行了综述，以确定OCT在神经眼科中的应用价值。
分析了时域OCT测量RNFL厚度的临床应用。通过PubMed搜索引擎，使用以下关键词选择相关出版物：“视神经病变”、“视网膜神经纤维层厚度”和“光学相干断层扫描”。本综述排除了有关青光眼的出版物。
RNFL厚度的变化过程取决于潜在疾病：（I）逐渐变薄直至萎缩（如视神经炎、视交叉受压），或（II）RNFL厚度最初增加，随后朝着（IIa）恢复正常（视乳头水肿）或（IIb）萎缩（前部缺血性视神经病变、Leber遗传性视神经病变）发展。
根据前视觉通路损伤的类型，OCT可提供与诊断、随访及预后相关的RNFL数据。与黄斑疾病一样，OCT已成为神经眼科常规疾病评估的重要临床工具。
