Sekeroglu V, Sekeroglu Z Atli, Demirhan Es
1Department of Biology, Faculty of Science and Letters, Ordu University, Ordu, Turkey.
Toxicol Ind Health. 2014 Feb;30(1):40-6. doi: 10.1177/0748233712448114. Epub 2012 Jun 7.
Deltamethrin (DEL) and thiacloprid (THIA) are the two commonly used synthetic insecticides applied either separately or as a mixture. The aim of this study was to assess thyroid stimulating hormone (TSH) and the serum levels of thyroid hormones exposure to these compounds in rats. The animals were orally gavaged with a single dose of DEL (15 mg/kg), THIA (112.5 mg/kg) or DEL + THIA (15 + 112.5 mg/kg) for 24 h (acute treatments) or DEL (3 mg/kg per day), THIA (22.5 mg/kg per day) or DEL + THIA (3 + 22.5 mg/kg per day) for 30 days (subacute treatments). Although all independent and combined treatments with DEL and THIA changed the levels of TSH, these alterations were not significant. Statistically significant increases in free triiodothyronine (FT3) and free thyroxine (FT4) serum hormone levels were observed in the independent treatment with THIA and the combined treatment with DEL and THIA for 30 days. The results of this study suggest that in vivo exposure to subacute treatments of commercial formulations of THI and mixture of DEL + THIA increased serum FT3 and FT4 levels in rats. Further studies are required to determine the effects of endocrine disruptors and potential health risks of these insecticides in human, especially in children because of the importance of these hormones during growth and development.
溴氰菊酯（DEL）和噻虫啉（THIA）是两种常用的合成杀虫剂，可单独使用或混合使用。本研究的目的是评估大鼠接触这些化合物后促甲状腺激素（TSH）和甲状腺激素的血清水平。给动物口服单剂量的DEL（15毫克/千克）、THIA（112.5毫克/千克）或DEL + THIA（15 + 112.5毫克/千克），持续24小时（急性处理），或口服DEL（每天3毫克/千克）、THIA（每天22.5毫克/千克）或DEL + THIA（每天3 + 22.5毫克/千克），持续30天（亚急性处理）。虽然DEL和THIA的所有独立及联合处理均改变了TSH水平，但这些改变并不显著。在THIA独立处理以及DEL和THIA联合处理30天的情况下，观察到游离三碘甲状腺原氨酸（FT3）和游离甲状腺素（FT4）血清激素水平有统计学意义的升高。本研究结果表明，大鼠体内接触THI商业制剂以及DEL + THIA混合物的亚急性处理会增加血清FT3和FT4水平。由于这些激素在生长发育过程中的重要性，需要进一步研究以确定这些内分泌干扰物对人类尤其是儿童的影响以及这些杀虫剂的潜在健康风险。
