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[雷安匹林和马福索对急性中毒性肝损伤模型的比较评价]

[Comparative evaluation of reamberin and mafusol on acute toxic liver damage models].

作者信息

Petrov A Iu, Zaplutanov V A, Sukhanov D S, Romantsov M G, Kovalenko A L

出版信息

Eksp Klin Farmakol. 2012;75(3):21-5.

PMID:22679749
Abstract

Comparative evaluation of the infusion of reamberin and mafusol has been carried out on the model of toxic liver damage caused by ammonium chloride. Reamberin contributed to more rapid normalization of indices due to an increase in the substrate reserve for energy metabolism. In a group of animals with alcohol intoxication, only the treatment with Reamberin allowed the system of antioxidant protection (reduced glutathione, thiol groups) and functional activity of the liver to be to normalized by the end of experiments on a level of the control group (intact animals).

摘要

在氯化铵所致中毒性肝损伤模型上,对雷安匹林和马福索的输注进行了比较评估。由于能量代谢底物储备增加,雷安匹林有助于各项指标更快恢复正常。在酒精中毒动物组中,只有用雷安匹林治疗能使抗氧化保护系统(还原型谷胱甘肽、巯基)和肝脏功能活性在实验结束时恢复到对照组(未受损动物)的水平。

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