Antibiot Khimioter. 2013;58(3-4):33-6.
The use of reamberin for prophylaxis of side effects was estimated in 257 patients with tuberculosis of the respiratory organs under the chemotherapy. The reference group involved 241 patients treated with the chemotherapeutics alone. Reamberin in the treatment of the patients, including subjects with multidrug resistant Mycobacterium tuberculosis, promoted a 2-fold decrease in the frequency of the intoxication syndrome during the first month of the treatment. Adverse reactions (toxic, allergic) to the antituberculosis chemotherapeuties were 2.4 times less frequent in the patients additionally treated with reamberin. Positive effect of reamberin on the activity of AIAT and AsAT was observed, the effect being higher, when the pathogen was susceptible to the drugs.
对257例接受化疗的呼吸器官结核患者使用雷安匹林预防副作用进行了评估。对照组有241例患者仅接受化疗药物治疗。雷安匹林用于治疗患者，包括耐多药结核分枝杆菌患者，在治疗的第一个月内使中毒综合征的发生率降低了两倍。接受雷安匹林辅助治疗的患者对抗结核化疗药物的不良反应（毒性、过敏）发生率降低了2.4倍。观察到雷安匹林对丙氨酸氨基转移酶（AIAT）和天冬氨酸氨基转移酶（AsAT）活性有积极作用，当病原体对药物敏感时，这种作用更强。
