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[经皮脊髓电刺激:激活人类运动神经回路的非侵入性工具]

[Transcutaneous electrical stimulation of the spinal cord: non-invasive tool for activation of locomotor circuitry in human].

作者信息

Gorodnichev R M, Pivovarova E A, Pukhov A, Moiseev S A, Savokhin A A, Moshonkina T R, Shcherbakova N A, Kilimnik V A, Selionov V A, Kozlovskaia I B, Edgerton V R, Gerasimenko Iu P

出版信息

Fiziol Cheloveka. 2012 Mar-Apr;38(2):46-56.

PMID:22679796
Abstract

A new tool for locomotor circuitry activation in the non-injured human by transcutaneous electrical spinal cord stimulation (tSCS) has been described. We show that continuous tSCS over T11-T12 vertebrae at 5-40 Hz induced involuntary locomotor-like stepping movements in subjects with their legs in a gravity-independent position. The increase of frequency of tSCS from 5 to 30 Hz augmented the amplitude of evoked stepping movements. The duration of cycle period did not depend on frequency of tSCS. During tSCS the hip, knee and ankle joints were involved in the stepping performance. It has been suggested that tSCS activates the locomotor circuitry through the dorsal roots. It appears that tSCS can be used as a non-invasive method in rehabilitation of spinal pathology.

摘要

一种通过经皮脊髓电刺激(tSCS)激活未受伤人体运动神经回路的新工具已被描述。我们发现,在T11 - T12椎骨上以5 - 40赫兹进行连续tSCS,能在腿部处于失重位置的受试者中诱发类似非自主运动的踏步动作。tSCS频率从5赫兹增加到30赫兹时,诱发的踏步动作幅度增大。周期时长并不取决于tSCS的频率。在tSCS期间,髋、膝和踝关节参与了踏步动作。有人提出,tSCS通过背根激活运动神经回路。似乎tSCS可作为一种非侵入性方法用于脊髓疾病的康复治疗。

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1
[Transcutaneous electrical stimulation of the spinal cord: non-invasive tool for activation of locomotor circuitry in human].[经皮脊髓电刺激:激活人类运动神经回路的非侵入性工具]
Fiziol Cheloveka. 2012 Mar-Apr;38(2):46-56.
2
[Novel method for activation of the locomotor circuitry in human].[激活人类运动神经回路的新方法]
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Initiation and modulation of locomotor circuitry output with multisite transcutaneous electrical stimulation of the spinal cord in noninjured humans.在未受伤的人类中,通过脊髓多部位经皮电刺激启动和调节运动神经回路输出。
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Spinal reflex in human lower leg muscles evoked by transcutaneous spinal cord stimulation.经皮脊髓刺激诱发的人体小腿肌肉脊髓反射
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Integration of sensory, spinal, and volitional descending inputs in regulation of human locomotion.感觉、脊髓和随意性下行输入在人类运动调节中的整合。
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Immediate Effects of Transcutaneous Spinal Cord Stimulation on Motor Function in Chronic, Sensorimotor Incomplete Spinal Cord Injury.经皮脊髓刺激对慢性感觉运动不完全性脊髓损伤患者运动功能的即时影响
J Clin Med. 2020 Nov 2;9(11):3541. doi: 10.3390/jcm9113541.

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Postsynaptic potentials of soleus motor neurons produced by transspinal stimulation: a human single-motor unit study.
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Transcutaneous spinal stimulation in people with and without spinal cord injury: Effect of electrode placement and trains of stimulation on threshold intensity.经皮脊髓刺激在脊髓损伤患者和非脊髓损伤患者中的应用:电极放置和刺激模式对阈值强度的影响。
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Priming locomotor training with transspinal stimulation in people with spinal cord injury: study protocol of a randomized clinical trial.经皮脊柱电刺激联合运动想象疗法治疗脊髓损伤患者的随机临床试验研究方案
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