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本文引用的文献

1
CNVs: harbingers of a rare variant revolution in psychiatric genetics.CNVs:精神遗传学中罕见变异革命的先兆。
Cell. 2012 Mar 16;148(6):1223-41. doi: 10.1016/j.cell.2012.02.039.
2
A systematic survey of loss-of-function variants in human protein-coding genes.人类蛋白编码基因功能丧失变异的系统调查。
Science. 2012 Feb 17;335(6070):823-8. doi: 10.1126/science.1215040.
3
Using pharmacogenetics in real time to guide warfarin initiation: a clinician update.实时应用药物遗传学指导华法林起始治疗:临床医生最新资讯
Circulation. 2011 Dec 6;124(23):2554-9. doi: 10.1161/CIRCULATIONAHA.111.019737.
4
A CFTR potentiator in patients with cystic fibrosis and the G551D mutation.囊性纤维化跨膜电导调节因子增效剂治疗囊性纤维化跨膜电导调节因子 G551D 突变患者。
N Engl J Med. 2011 Nov 3;365(18):1663-72. doi: 10.1056/NEJMoa1105185.
5
Whole-genome sequencing for optimized patient management.全基因组测序优化患者管理。
Sci Transl Med. 2011 Jun 15;3(87):87re3. doi: 10.1126/scitranslmed.3002243.
6
Genetics of antipsychotic-induced side effects and agranulocytosis.抗精神病药引起的副作用和粒细胞缺乏症的遗传学。
Curr Psychiatry Rep. 2011 Apr;13(2):156-65. doi: 10.1007/s11920-011-0185-3.
7
Evidence-based classification of recommendations on use of genomic tests in clinical practice: dealing with insufficient evidence.基于证据的临床实践中基因组检测应用推荐分类:处理证据不足的情况。
Genet Med. 2010 Nov;12(11):680-3. doi: 10.1097/GIM.0b013e3181f9ad55.
8
Antidepressant response and the serotonin transporter gene-linked polymorphic region.抗抑郁反应与 5-羟色胺转运体基因连锁多态区。
Biol Psychiatry. 2010 Sep 15;68(6):536-43. doi: 10.1016/j.biopsych.2010.04.034. Epub 2010 Jul 7.
9
Genomic medicine--an updated primer.基因组医学——最新入门指南。
N Engl J Med. 2010 May 27;362(21):2001-11. doi: 10.1056/NEJMra0907175.
10
Training in psychiatric genomics during residency: a new challenge.住院医师规范化培训中的精神遗传学培训:新挑战。
Acad Psychiatry. 2010 Mar-Apr;34(2):115-8. doi: 10.1176/appi.ap.34.2.115.

神经精神药理学中的药物基因组学和个性化医学。

Pharmacogenomics and personalized medicine in neuropsychiatry.

机构信息

National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892-3719, USA.

出版信息

Neuron. 2012 Jun 7;74(5):773-6. doi: 10.1016/j.neuron.2012.05.004.

DOI:10.1016/j.neuron.2012.05.004
PMID:22681682
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3407812/
Abstract

Despite the need for more effective treatments for psychiatric disorders, development of new medications has stalled. Here we discuss the promise of personalized medicine in developing more efficacious and individualized pharmacotherapies that take into account genetic variation and target groups of patients who share biology, not just symptoms.

摘要

尽管我们需要更有效的精神疾病治疗方法,但新药物的研发已经停滞不前。在这里,我们讨论了个性化医学在开发更有效和个体化药物治疗方面的前景,这些治疗方法考虑了遗传变异,并针对具有共同生物学特征而非仅仅是症状的患者群体。