Washington University School of Medicine, Department of Psychiatry, St. Louis, MO 63110, USA.
Drug Alcohol Depend. 2012 Nov 1;126(1-2):102-10. doi: 10.1016/j.drugalcdep.2012.04.024. Epub 2012 Jun 8.
Outcome expectancy is a central construct in models of addiction and relapse. Much expectancy research has been conducted in the context of alcohol; however, less is known about the structure of expectancies for marijuana and their associations with marijuana use outcomes.
The data are taken from waves 3 and 4 of a longitudinal high-risk study of parents and adolescent offspring. Of those families who were retained at wave 3, 225 were high-risk and 205 were matched controls (low-risk). In the present study, we examine the factorial structure of marijuana expectancies (wave 3) in the offspring (using an instrument adapted from the alcohol literature) and test whether expectancies mediate the associations of familial risk for substance use, lifetime marijuana use in adolescence (wave 3) and current use in young adulthood (wave 4; reported approximately 5 years later).
We quantified four marijuana expectancy factors similar to those identified in previous studies when the offspring were adolescents (Mn age=15.2) and results of our mediation models suggest that negative marijuana expectancies (but not positive expectancies) together with lifetime adolescent marijuana use completely mediated the association between familial risk and current use of marijuana during young adulthood (Mn age=20.2).
Familial risk for current marijuana use in young adulthood appears to be transmitted through two orthogonal, prospective pathways. One pathway involves marijuana use during adolescence, and the second pathway involves reduced expectancies that using marijuana will result in cognitive and behavioral impairments.
预期结果是成瘾和复发模型中的一个核心结构。许多预期研究都是在酒精的背景下进行的;然而,对于大麻的预期结构及其与大麻使用结果的关系,人们知之甚少。
数据来自一项对父母和青少年后代进行的纵向高危研究的第 3 波和第 4 波。在第 3 波中保留下来的那些家庭中,225 个是高危家庭,205 个是匹配的对照组(低危家庭)。在本研究中,我们检验了青少年(使用改编自酒精文献的工具)大麻预期的因子结构(第 3 波),并测试了预期是否在家族物质使用风险、青少年时期的终生大麻使用(第 3 波)和成年早期的当前使用(第 4 波;大约 5 年后报告)之间的关联中起中介作用。
我们量化了四个大麻预期因素,与青少年时期(平均年龄=15.2)识别的因素相似,我们的中介模型结果表明,消极的大麻预期(而不是积极的预期)与青少年时期的终生大麻使用一起,完全中介了家族风险与成年早期当前大麻使用之间的关联。
在成年早期,当前大麻使用的家族风险似乎通过两个正交的前瞻性途径传递。一个途径涉及青少年时期的大麻使用,另一个途径涉及使用大麻不会导致认知和行为障碍的预期降低。