在由β-肾上腺素能受体激动剂克仑特罗或肌腱切断术诱导的骨骼肌肥大过程中，核糖体与肌原纤维的结合增加。
Increased association of ribosomes with myofibrils during the skeletal-muscle hypertrophy induced either by the beta-adrenoceptor agonist clenbuterol or by tenotomy.
作者信息
Horne Z, Hesketh J
机构信息
Division of Biochemical Sciences, Rowett Research Institute, Bucksburn, Aberdeen, U.K.
出版信息
Biochem J. 1990 Dec 15;272(3):831-3. doi: 10.1042/bj2720831.
Abstract
Ribosome distribution in skeletal-muscle myofibres was investigated by immunohistochemistry and microdensitometry by using anti-(60 S ribosomal subunit) antibodies. Administration of the beta-adrenoceptor agonist clenbuterol caused an increase in the staining of the myofibrillar region with this antibody relative to that found in the subsarcolemmal cytoplasm. A similar effect was observed during hypertrophy of the plantaris muscle following severance of the tendon to the gastrocnemius. The results suggest that increased association of ribosomes with the myofibrils occurs during muscle hypertrophy.
摘要
通过免疫组织化学和显微密度测定法，使用抗（60S核糖体亚基）抗体研究了核糖体在骨骼肌肌纤维中的分布。给予β-肾上腺素能受体激动剂克伦特罗后，相对于肌膜下细胞质中的情况，该抗体对肌原纤维区域的染色增加。在切断跟腱导致比目鱼肌肥大的过程中也观察到了类似的效果。结果表明，在肌肉肥大过程中，核糖体与肌原纤维的结合增加。
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