Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada.
Curr Opin Cell Biol. 2012 Aug;24(4):541-6. doi: 10.1016/j.ceb.2012.05.005. Epub 2012 Jun 8.
The centrosome is a subcellular organelle that is responsible for the majority of microtubule organization. Through this ability, the centrosome is involved in cell division, migration, and polarization. Recent studies have revealed intriguing asymmetries between mother and daughter centrioles as well as between mother and daughter centrosomes, and the involvement of such asymmetries in multiple cellular and developmental processes. This review aims to summarize recent discoveries on such asymmetries in centrioles/centrosomes and the potential implication of their inheritance patterns during cell division and development.
中心体是一种负责大多数微管组织的亚细胞细胞器。通过这种能力，中心体参与细胞分裂、迁移和极化。最近的研究揭示了母和子中心粒以及母和子中心体之间有趣的不对称性，以及这种不对称性在多个细胞和发育过程中的参与。本综述旨在总结最近关于中心粒/中心体的这种不对称性的发现，以及它们在细胞分裂和发育过程中的遗传模式的潜在意义。
