Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Cancer Metastasis Rev. 2012 Dec;31(3-4):653-62. doi: 10.1007/s10555-012-9368-6.
The great majority of cancer deaths are due to metastasis, which remains a poorly understood pathological process. The formation of a metastasis reflects a succession of complex steps leading to the macroscopic outgrowth of disseminated tumor cells at the secondary site. In the past 5 years, certain microRNAs (miRNAs) have been shown to regulate either a single step or multiple steps of metastasis, doing so by downregulating the expression of their target genes. In this review, we discuss recent studies on the functions and molecular mechanisms of miRNAs in regulating epithelial-mesenchymal transition (EMT) and cancer metastasis.
绝大多数癌症死亡是由于转移，这仍然是一个了解甚少的病理过程。转移的形成反映了一系列复杂的步骤，导致播散的肿瘤细胞在次级部位的宏观生长。在过去的 5 年中，某些 microRNAs（miRNAs）已被证明可以调节转移的单个步骤或多个步骤，通过下调其靶基因的表达来实现。在这篇综述中，我们讨论了 miRNA 在调节上皮-间充质转化（EMT）和癌症转移中的功能和分子机制的最新研究。
