Department of OB & GYN, Hadassah Hebrew University Medical Center, Jerusalem, Israel.
Gynecol Endocrinol. 2012 Dec;28(12):993-8. doi: 10.3109/09513590.2012.692001. Epub 2012 Jun 12.
Thyroid physiology is altered during pregnancy as a result of an increase in thyroid-binding globulin, the stimulatory effect of hCG on TSH receptors, and increased peripheral thyroid hormone requirements. In addition, hyper and hypothyroid disorders are prevalent among women of reproductive age, and most of them have a significant impact on the gravida, fetus and neonate. Aberrant thyroid function can be readily recognized and treated during pregnancy, avoiding such complications. Here, we will review the thyroid function changes occurring during pregnancy, the different disorders, their maternal and fetal implications, and the ways to screen, prevent and treat these conditions.
怀孕期间甲状腺生理发生改变,这是由于甲状腺结合球蛋白增加、hCG 对 TSH 受体的刺激作用以及外周甲状腺激素需求增加所致。此外,妊娠年龄的妇女中甲状腺功能亢进和减退症很常见,其中大多数对孕妇、胎儿和新生儿有重大影响。在怀孕期间,可轻易识别和治疗异常甲状腺功能,从而避免此类并发症。在这里,我们将回顾怀孕期间甲状腺功能变化、不同疾病及其对母体和胎儿的影响,以及筛查、预防和治疗这些疾病的方法。