Physical Activity and Aging Lab, Institute of Biosciences, São Paulo State University, Rio Claro, São Paulo, Brazil.
Geriatr Gerontol Int. 2013 Jan;13(1):198-203. doi: 10.1111/j.1447-0594.2012.00887.x. Epub 2012 Jun 11.
The objective of the present study was to investigate the effect of a multimodal exercise intervention on frontal cognitive functions and kinematic gait parameters in patients with Alzheimer's disease.
A sample of elderly patients with Alzheimer's disease (n=27) were assigned to a training group (n=14; aged 78.0±7.3 years) and a control group (n=13; aged 77.1±7.4 years). Multimodal exercise intervention includes motor activities and cognitive tasks simultaneously. The participants attended a 1-h session three times a week for 16 weeks, and the control participants maintained their regular daily activities during the same period. The frontal cognitive functions were evaluated using the Frontal Assessment Battery, the Clock Drawing Test and the Symbol Search Subtest. The kinematic parameters of gait-cadence, stride length and stride speed were analyzed under two conditions: (i) free gait (single task); and (ii) gait with frontal cognitive task (walking and counting down from 20--dual task).
The patients in the intervention group significantly increased the scores in frontal cognitive variables, Frontal Assessment Battery (P<0.001) and Symbol Search Subtest (P<0.001) after the 16-week period. The control group decreased the scores in the Clock Drawing Test (P=0.001) and increased the number of counting errors during the dual task (P=0.008) after the same period.
The multimodal exercise intervention improved the frontal cognitive functions in patients with Alzheimer's disease.
本研究旨在探讨多模式运动干预对阿尔茨海默病患者前额认知功能和运动步态参数的影响。
将 27 例老年阿尔茨海默病患者分为训练组（n=14；年龄 78.0±7.3 岁）和对照组（n=13；年龄 77.1±7.4 岁）。多模式运动干预包括同时进行运动活动和认知任务。参与者每周参加 3 次、每次 1 小时的训练，持续 16 周，而对照组在同一时期保持日常活动。使用额叶评估量表、画钟测验和符号搜索测验评估前额认知功能。在两种情况下分析步态节律、步长和步速的运动学参数：（i）自由步态（单任务）；和（ii）带有前额认知任务的步态（行走并从 20 倒数-双重任务）。
干预组患者在 16 周后，额叶认知变量、额叶评估量表（P<0.001）和符号搜索测验（P<0.001）的评分显著增加。对照组在同一时期后，画钟测验（P=0.001）的评分下降，双重任务中的计数错误次数增加（P=0.008）。
多模式运动干预改善了阿尔茨海默病患者的前额认知功能。
