Department of Hepatology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.
Digestion. 2012;86(1):1-5. doi: 10.1159/000337529. Epub 2012 Jun 8.
BACKGROUND/AIMS: Simultaneous assessment of biochemical, virological, and histological parameters of incidentally detected chronic hepatitis B virus (HBV)-infected subjects in Bangladesh were done to develop strategies for containment of HBV and management of liver diseases of these patients.
A total of 702 chronic HBV carriers detected incidentally were enrolled in the study. Levels of HBV DNA and alanine aminotransferase (ALT) in sera were measured. The extent of hepatic inflammation and liver fibrosis was evaluated in all patients by examining liver biopsy specimens.
Of the 702 patients, 358 (50.7%) exhibited HBV DNA levels >10(5) copies/ml. ALT levels were above the upper limit of normal (ULN; >42 U/l) in more than 50% of the patients. High levels of HBV DNA (>10(5) copies/ml), increased ALT (>1.0 × ULN), moderate hepatic inflammation (HAI-NI ≥7) and severe hepatic fibrosis (HAI-F ≥3) were detected in 60 patients.
As considerable numbers of apparently healthy subjects are unaware of the fact that they are chronically infected by HBV, many of whom have already developed progressive liver damage, emergency strategies would be needed for the containment and management of HBV infection in developing countries.
背景/目的：在孟加拉国，对偶然发现的慢性乙型肝炎病毒（HBV）感染者的生化、病毒学和组织学参数进行了同时评估，以制定控制 HBV 和管理这些患者肝病的策略。
本研究共纳入 702 例偶然发现的慢性 HBV 携带者。检测血清中 HBV DNA 和丙氨酸氨基转移酶（ALT）的水平。所有患者均通过检查肝活检标本来评估肝炎症和肝纤维化的程度。
702 例患者中，358 例（50.7%）HBV DNA 水平>10^5 拷贝/ml。超过 50%的患者 ALT 水平高于正常值上限（ULN；>42 U/l）。在 60 例患者中，检测到高 HBV DNA（>10^5 拷贝/ml）、ALT 升高（>1.0 × ULN）、中度肝炎症（HAI-NI≥7）和严重肝纤维化（HAI-F≥3）。
由于相当多的表面健康的人不知道他们实际上已经被 HBV 慢性感染，其中许多人已经出现了进行性的肝损伤，因此发展中国家需要紧急策略来控制和管理 HBV 感染。
