用于区域血容量测量的人血清白蛋白二硫代氨基脲（HSA-DTS）偶联物的62Cu标记：新型62Zn/62Cu发生器系统的应用
62Cu-labeling of human serum albumin-dithiosemicarbazone (HSA-DTS) conjugate for regional plasma volume measurement: application of new 62Zn/62Cu generator system.
作者信息
Fujibayashi Y, Matsumoto K, Arano Y, Yonekura Y, Konishi J, Yokoyama A
机构信息
Department of Nuclear Medicine, School of Medicine, Kyoto University, Japan.
出版信息
Chem Pharm Bull (Tokyo). 1990 Jul;38(7):1946-8. doi: 10.1248/cpb.38.1946.
62Cu-Labeling of human serum albumin-dithiosemicarbazone (HSA-DTS) conjugate was performed using a newly developed 62Zn/62Cu generator system. HSA-DTS was easily labeled with 62Cu, by simple mixing with 62Cu-generator eluate. In vivo blood clearance of 62Cu-HSA-DTS was similar to 131I-HSA, indicating the high applicability of 62Cu-HSA-DTS as a method for plasma volume measurement. In a positron emission tomography study of a dog, a clear plasma pool image of the head region was obtained.
使用新开发的62Zn/62Cu发生器系统对人血清白蛋白-二硫代氨基脲（HSA-DTS）偶联物进行62Cu标记。通过与62Cu发生器洗脱液简单混合，HSA-DTS很容易被62Cu标记。62Cu-HSA-DTS的体内血液清除率与131I-HSA相似，表明62Cu-HSA-DTS作为血浆容量测量方法具有很高的适用性。在对一只狗的正电子发射断层扫描研究中，获得了清晰的头部区域血浆池图像。
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