Okazawa H, Fujibayashi Y, Yonekura Y, Tamaki N, Nishizawa S, Magata Y, Ishizu K, Tsuchida T, Sadato N, Konishi J
Department of Nuclear Medicine, Kyoto University School of Medicine, Japan.
Ann Nucl Med. 1995 May;9(2):81-7. doi: 10.1007/BF03164971.
We have developed a new 62Zn/62Cu positron generator, and applied it for PET imaging of perfusion and plasma volume in 5 normal subjects. The generator makes it possible by a simple procedure to obtain 62Cu eluate and labeling compounds sufficiently every 40-60 minutes. 62Cu labeled pyruvaldehyde bis(N4-methylthiosemicarbazone) copper II (62Cu-PTSM) was employed for cerebral and myocardial perfusion imaging and 62Cu labeled human serum albumin-dithiosemicarbazone (62Cu-HSA-DTS) was used for plasma pool imaging. The images of cerebral blood flow, cerebral plasma volume and myocardial perfusion were excellent. In addition, the analysis of tissue activity and blood activity demonstrated the microspheric character of 62Cu-PTSM. Correction of arterial activity with the standard disappearance curve of 62Cu-PTSM suggested the possibility of quantifying blood flow. The results of this study indicate the capability of the 62Zn/62Cu generator for wide clinical use without an in-house cyclotron.
我们研发了一种新型的62Zn/62Cu正电子发生器，并将其应用于5名正常受试者的灌注和血容量PET成像。该发生器通过简单的程序，每40 - 60分钟就能充分获得62Cu洗脱液和标记化合物。62Cu标记的丙酮醛双（N4-甲基硫代半卡巴腙）铜II（62Cu-PTSM）用于脑和心肌灌注成像，62Cu标记的人血清白蛋白-二硫代半卡巴腙（62Cu-HSA-DTS）用于血池成像。脑血流、脑血容量和心肌灌注的图像质量良好。此外，组织活性和血液活性分析表明62Cu-PTSM具有微球特性。用62Cu-PTSM的标准消失曲线校正动脉活性提示了血流定量的可能性。本研究结果表明，62Zn/62Cu发生器无需配备医院内部回旋加速器即可广泛应用于临床。
