Fujibayashi Y, Matsumoto K, Yonekura Y, Konishi J, Yokoyama A
Department of Radiopharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University, Japan.
J Nucl Med. 1989 Nov;30(11):1838-42.
A new 62Zn/62Cu generator system was designed to provide a readily available 62Cu source for positron emission tomographic radiopharmaceuticals, based on the differences of complex formation between Zn and Cu. Noncarrier added 62Cu was selectively eluted as a glycine complex from 62Zn-adsorbed cation-exchange resin (CG-120, Amberlite), when a glycine solution (200 mM) was used as the eluant. The elution efficiency and radionuclidic purity of 62Cu were 70% and greater than 99.9%, respectively. Copper in glycine solution showed rapid complex formation with dithiosemicarbazone, which is one of the established Cu-binding agents for bifunctional chelating radiopharmaceutical.
基于锌和铜形成配合物的差异，设计了一种新型的62Zn/62Cu发生器系统，以提供用于正电子发射断层显像放射性药物的现成62Cu源。当使用甘氨酸溶液（200 mM）作为洗脱剂时，无载体添加的62Cu作为甘氨酸配合物从吸附有62Zn的阳离子交换树脂（CG-120，Amberlite）中被选择性洗脱。62Cu的洗脱效率和放射性核素纯度分别为70%和大于99.9%。甘氨酸溶液中的铜与二硫代氨基脲迅速形成配合物，二硫代氨基脲是用于双功能螯合放射性药物的一种已确定的铜结合剂。
